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Ozawade
Eintrag öffnenOzawade · 4.1 Therapeutic indications · 1
Eintrag öffnenOzawade · 4.3 Contraindications · 1
Eintrag öffnenOzawade · 4.3 · Breastfeeding (see section 4.6).
Eintrag öffnenOzawade · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenOzawade · 4.3 · Severe hepatic impairment (Child-Pugh C).
Eintrag öffnenOzawade · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenOzawade · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenOzawade · 4.5 · - CYP3A4 inhibitors
Eintrag öffnenOzawade · 4.5 · - Enzyme inducers CYP3A inducers will most likely have an effect on the pharmacokinetics of pitolisant in CYP2
Eintrag öffnenOzawade · 4.5 · - Other In a clinical multiple dose study, the combination of pitolisant with probenecid decreases the AUC of
Eintrag öffnenOzawade · 4.5 · - Other The combination of pitolisant with modafinil or sodium oxybate was evaluated in healthy volunteers, at
Eintrag öffnenOzawade · 4.5 · - Substrates of OCT1 Pitolisant may be a clinically relevant inhibitor of OCT1 based on in vitro data and a cl
Eintrag öffnenOzawade · 4.5 · 5 Based on the in vitro biotransformation pathway, CYP3A4 inhibitors may have an impact on the pharmacokinetic
Eintrag öffnenOzawade · 4.5 · Anti-histamines
Eintrag öffnenOzawade · 4.5 · Anti-histamines (H1-receptor antagonists) crossing the haemato-encephalic barrier (e.g. pheniramine maleate, c
Eintrag öffnenOzawade · 4.5 · Antidepressants
Eintrag öffnenOzawade · 4.5 · Combination with pitolisant should be made with a careful monitoring (see section 4.4).
Eintrag öffnenOzawade · 4.5 · Even if the clinical relevance of this effect is not established, caution is advised when pitolisant is admini
Eintrag öffnenOzawade · 4.5 · In subjects that are CYP2D6 intermediate, extensive (normal) or ultra-rapid metabolizers, CYP2D6 is the main e
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