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Perjeta
Eintrag öffnenPerjeta · 4.1 Therapeutic indications · 1
Eintrag öffnenPerjeta · 4.3 Contraindications · 1
Eintrag öffnenPerjeta · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenPerjeta · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenPerjeta · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenPerjeta · 4.5 · Five studies evaluated the effects of pertuzumab on the PK of co-administered cytotoxic agents, docetaxel, pac
Eintrag öffnenPerjeta · 4.5 · No pharmacokinetic (PK) interactions were observed between pertuzumab and trastuzumab, or between pertuzumab a
Eintrag öffnenPerjeta · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenPerjeta · 4.8 Undesirable effects · 1
Eintrag öffnenPerjeta · 4.8 · * ADRs with a fatal outcome have been reported. ** For the overall treatment period across the 4 studies. The
Eintrag öffnenPerjeta · 4.8 · 11 Febrile neutropenia In the pivotal trial CLEOPATRA, the majority of patients in both treatment groups exper
Eintrag öffnenPerjeta · 4.8 · 12 occurred in the first two cycles, and responded to standard therapies, such as topical or oral treatment fo
Eintrag öffnenPerjeta · 4.8 · 8 In addition, ADRs reported in the post-marketing setting are included in Table 2. As Perjeta was used with t
Eintrag öffnenPerjeta · 4.8 · 9 System organ class Very Common Common Uncommon Rare
Eintrag öffnenPerjeta · 4.8 · Blood and lymphatic Febrile neutropenia* system Neutropenia disorders Leucopenia Anaemia Immune system disorde
Eintrag öffnenPerjeta · 4.8 · Constipation Dyspepsia Abdominal pain Skin and subcutaneous Alopecia tissue disorders Rash Nail disorder Pruri
Eintrag öffnenPerjeta · 4.8 · Description of selected adverse reactions
Eintrag öffnenPerjeta · 4.8 · Diarrhoea In the pivotal trial CLEOPATRA in metastatic breast cancer, diarrhoea occurred in 68.4% of Perjeta-
Eintrag öffnenPerjeta · 4.8 · During the second cycle when all medicinal products were administered on the same day, the most common infusio
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