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Polivy
Eintrag öffnenPolivy · 4.1 Therapeutic indications · 1
Eintrag öffnenPolivy · 4.3 Contraindications · 1
Eintrag öffnenPolivy · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. Active severe infe
Eintrag öffnenPolivy · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenPolivy · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenPolivy · 4.5 · 9 Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenobarbital, phenytoin, St John’s wort [Hypericum
Eintrag öffnenPolivy · 4.5 · Based on physiological-based pharmacokinetic (PBPK) model simulations of MMAE released from polatuzumab vedoti
Eintrag öffnenPolivy · 4.5 · Bendamustine does not affect acMMAE and unconjugated MMAE plasma AUC.
Eintrag öffnenPolivy · 4.5 · Drug interactions of rituximab, bendamustine, cyclophosphamide, and doxorubicin in combination with polatuzuma
Eintrag öffnenPolivy · 4.5 · Drug interactions with concomitant medicines that are CYP3A4 inhibitors, substrates or inducers and co-medicat
Eintrag öffnenPolivy · 4.5 · No dedicated clinical drug-drug interaction studies with polatuzumab vedotin in humans have been conducted.
Eintrag öffnenPolivy · 4.5 · The pharmacokinetics (PK) of rituximab, bendamustine, cyclophosphamide, and doxorubicin are not affected by co
Eintrag öffnenPolivy · 4.5 · Unconjugated MMAE is not predicted to alter the AUC of concomitant medicines that are CYP3A4 substrates (e.g.,
Eintrag öffnenPolivy · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenPolivy · 4.8 Undesirable effects · 1
Eintrag öffnenPolivy · 4.8 · 11 Blood and lymphatic system disorders Very common febrile neutropenia, neutropenia, thrombocytopenia, anaemi
Eintrag öffnenPolivy · 4.8 · 12 a ADR associated with fatal outcome b ADRs observed in relapsed or refractory DLBCL only. c ADRs observed i
Eintrag öffnenPolivy · 4.8 · 13 In an open-label study GO29365, infections, including pneumonia and other types of infections, were reporte
Eintrag öffnenPolivy · 4.8 · Description of selected adverse drug reactions
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