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Dovprela (previously Pretomanid FGK)
Eintrag öffnenDovprela (previously Pretomanid FGK) · 4.1 Therapeutic indications · 1
Eintrag öffnenDovprela (previously Pretomanid FGK) · 4.3 Contraindications · 1
Eintrag öffnenDovprela (previously Pretomanid FGK) · 4.3 · Hypersensitivity to the active substance, other nitroimidazoles, or to any of the excipients listed in section
Eintrag öffnenDovprela (previously Pretomanid FGK) · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenDovprela (previously Pretomanid FGK) · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenDovprela (previously Pretomanid FGK) · 4.5 · CYP3A4 inducers Pretomanid is metabolized in part by CYP3A4. In consequence, exposure to pretomanid may be red
Eintrag öffnenDovprela (previously Pretomanid FGK) · 4.5 · Effect on CYP2C8, 2C9 and 2C19 substrates In vitro studies show that pretomanid is an inducer of CYP2C8 while
Eintrag öffnenDovprela (previously Pretomanid FGK) · 4.5 · Effect on OAT3, OATP1B3, P-gp and BCRP substrates Pretomanid is an inhibitor of the OAT3 transporter in vitro,
Eintrag öffnenDovprela (previously Pretomanid FGK) · 4.5 · Effects of other medicinal products on pretomanid
Eintrag öffnenDovprela (previously Pretomanid FGK) · 4.5 · Effects of pretomanid on other medicinal products
Eintrag öffnenDovprela (previously Pretomanid FGK) · 4.5 · In an interaction study of multiple-dose pretomanid with multiple-dose ritonavir-boosted-lopinavir, the AUC0-2
Eintrag öffnenDovprela (previously Pretomanid FGK) · 4.5 · In vitro studies indicate that pretomanid is an inhibitor of BCRP, OATP1B3 and P-gp. No clinical studies have
Eintrag öffnenDovprela (previously Pretomanid FGK) · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenDovprela (previously Pretomanid FGK) · 4.8 Undesirable effects · 1
Eintrag öffnenDovprela (previously Pretomanid FGK) · 4.8 · 10 Peripheral neuropathy Peripheral neuropathy is a known ADR of linezolid. In the Nix-TB trial, 81% (very com
Eintrag öffnenDovprela (previously Pretomanid FGK) · 4.8 · 7 ADRs attributed to moxifloxacin are marked with §.
Eintrag öffnenDovprela (previously Pretomanid FGK) · 4.8 · 8 System Organ Very Common Common Uncommon Class ≥1/10 ≥1/100 to <1/10 ≥1/1,000 to <1/100 Hepatobiliary Transa
Eintrag öffnenDovprela (previously Pretomanid FGK) · 4.8 · 9 Δ: ADRs that are attributed to linezolid. §: ADRs that are attributed to Moxifloxacin
Eintrag öffnenDovprela (previously Pretomanid FGK) · 4.8 · Description of selected adverse reactions
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