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Eintrag öffnenQtern · 4.1 Therapeutic indications · 1
Eintrag öffnenQtern · 4.3 Contraindications · 1
Eintrag öffnenQtern · 4.3 · Hypersensitivity to the active substances or to any of the excipients listed in section 6.1, or history of a s
Eintrag öffnenQtern · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenQtern · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenQtern · 4.5 · 7 did not alter the pharmacokinetics of saxagliptin or its major active metabolite.
Eintrag öffnenQtern · 4.5 · 8 valsartan, digoxin (a P-gp substrate) or warfarin (S-warfarin, a CYP2C9 substrate), or the anticoagulatory e
Eintrag öffnenQtern · 4.5 · Concomitant administration of saxagliptin with the potent CYP3A4/5 inducer rifampicin reduced Cmax and AUC of
Eintrag öffnenQtern · 4.5 · Concomitant administration of saxagliptin with the potent inhibitor of CYP3A4/5 ketoconazole, increased the Cm
Eintrag öffnenQtern · 4.5 · Dapagliflozin: Dapagliflozin did not meaningfully alter the pharmacokinetics of saxagliptin, metformin, piogli
Eintrag öffnenQtern · 4.5 · Dapagliflozin: Dapagliflozin may increase renal lithium excretion and the blood lithium levels may be decrease
Eintrag öffnenQtern · 4.5 · Dapagliflozin: Following coadministration of dapagliflozin with rifampicin (an inducer of various active trans
Eintrag öffnenQtern · 4.5 · Dapagliflozin: The metabolism of dapagliflozin is primarily via glucuronide conjugation mediated by UDP glucur
Eintrag öffnenQtern · 4.5 · Diuretics Dapagliflozin may add to the diuretic effect of thiazide and loop diuretics and may increase the ris
Eintrag öffnenQtern · 4.5 · Effect of other medicinal products on saxagliptin or dapagliflozin Saxagliptin: Concomitant administration of
Eintrag öffnenQtern · 4.5 · Effect of saxagliptin or dapagliflozin on other medicinal products Saxagliptin: Saxagliptin did not meaningful
Eintrag öffnenQtern · 4.5 · Following coadministration of dapagliflozin with mefenamic acid (an inhibitor of UGT1A9), a 55% increase in da
Eintrag öffnenQtern · 4.5 · In interaction studies conducted in healthy subjects, using mainly a single-dose design, dapagliflozin did not
Eintrag öffnenQtern · 4.5 · In studies conducted in healthy subjects, neither the pharmacokinetics of saxagliptin nor its major metabolite
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