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Quviviq
Eintrag öffnenQuviviq · 4.1 Therapeutic indications · 1
Eintrag öffnenQuviviq · 4.3 Contraindications · 1
Eintrag öffnenQuviviq · 4.3 · • Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. • Narcolepsy. •
Eintrag öffnenQuviviq · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenQuviviq · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenQuviviq · 4.5 · 5 No dose adjustment is required when QUVIVIQ is used concomitantly with treatments that reduce gastric acidit
Eintrag öffnenQuviviq · 4.5 · 6 Paediatric population
Eintrag öffnenQuviviq · 4.5 · Alcohol Co-administration of 50 mg daridorexant with alcohol led to additive effects on psychomotor performanc
Eintrag öffnenQuviviq · 4.5 · Alcohol In healthy subjects, concomitant intake with alcohol led to a prolonged absorption of daridorexant (tm
Eintrag öffnenQuviviq · 4.5 · Based on these results, concomitant use with a moderate or strong CYP3A4 inducer substantially decreases expos
Eintrag öffnenQuviviq · 4.5 · CYP3A4 inducers In healthy subjects, co-administration with efavirenz (600 mg once daily), a moderate CYP3A4 i
Eintrag öffnenQuviviq · 4.5 · CYP3A4 inhibitors In healthy subjects, co-administration of daridorexant 25 mg with the moderate CYP3A4 inhibi
Eintrag öffnenQuviviq · 4.5 · Citalopram In healthy subjects, co-administration of 20 mg citalopram, a selective serotonin re-uptake inhibit
Eintrag öffnenQuviviq · 4.5 · Citalopram In healthy subjects, the PK of citalopram at steady state was not affected by co-administration of
Eintrag öffnenQuviviq · 4.5 · Citalopram No relevant interaction on psychomotor performance was observed when 50 mg daridorexant was co-admi
Eintrag öffnenQuviviq · 4.5 · Effect of daridorexant on the pharmacokinetics of other medicinal products
Eintrag öffnenQuviviq · 4.5 · Effect of other medicinal products on the pharmacokinetics of daridorexant
Eintrag öffnenQuviviq · 4.5 · Gastric pH-modifiers The solubility of daridorexant is pH-dependent. In healthy subjects, co-administration wi
Eintrag öffnenQuviviq · 4.5 · In a clinical study conducted in healthy subjects receiving daridorexant 50 mg and dabigatran etexilate, a sen
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