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Rukobia
Eintrag öffnenRukobia · 4.1 Therapeutic indications · 1
Eintrag öffnenRukobia · 4.3 Contraindications · 1
Eintrag öffnenRukobia · 4.3 · Co-administration with strong CYP3A inducers including, but not limited to: carbamazepine, phenytoin, mitotane
Eintrag öffnenRukobia · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenRukobia · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenRukobia · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenRukobia · 4.5 · 4 Fostemsavir may be co-administered with strong CYP3A4, BCRP and/or P-gp inhibitors (e.g., clarithromycin, it
Eintrag öffnenRukobia · 4.5 · 5 Tenofovir alafenamide TAF This interaction has not been studied. (TAF) (inhibition of OATP1B1/3 Temsavir i
Eintrag öffnenRukobia · 4.5 · 7 Oral contraceptives: EE ↑ EE should not exceed 30 µg daily. Ethinyl estradiol (EE) AUC 39% Caution is advi
Eintrag öffnenRukobia · 4.5 · 8 Hepatitis C virus Direct- Grazoprevir This interaction has not been studied. Acting Antivirals (HCV (inhib
Eintrag öffnenRukobia · 4.5 · ATV RTV Darunavir (DRV)/cobicistat Temsavir Darunavir/cobicistat increased AUC 97% temsavir plasma con
Eintrag öffnenRukobia · 4.5 · Although not studied, concomitant use of fostemsavir and other strong CYP3A4 inducers is contraindicated (see
Eintrag öffnenRukobia · 4.5 · Although not studied, use the lowest possible starting dose of other statins that are substrates of OATP1B1/3
Eintrag öffnenRukobia · 4.5 · Concomitant medicinal Effect on concentration of Recommendation concerning co- product by therapeutic temsavir
Eintrag öffnenRukobia · 4.5 · DRV AUC 6% Cmax 2% C 5%
Eintrag öffnenRukobia · 4.5 · ETR Nevirapine (NVP) Temsavir This interaction has not been studied. (induction of CYP3A Nevirapine is exp
Eintrag öffnenRukobia · 4.5 · Effect of other medical products on the pharmacokinetics of temsavir
Eintrag öffnenRukobia · 4.5 · Effect of temsavir on the pharmacokinetics of other medicinal products
Eintrag öffnenRukobia · 4.5 · Etravirine 6 AUC 28% Cmax 18% C 28% Pharmacokinetic Enhancer Cobicistat (COBI) Temsavir Cobicistat
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