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Rydapt
Eintrag öffnenRydapt · 4.1 Therapeutic indications · 1
Eintrag öffnenRydapt · 4.3 Contraindications · 1
Eintrag öffnenRydapt · 4.3 · Concomitant administration of potent CYP3A4 inducers, e.g. rifampicin, St. John’s Wort (Hypericum perforatum),
Eintrag öffnenRydapt · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenRydapt · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenRydapt · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenRydapt · 4.5 · 7 Substrates of transporters In healthy subjects, co-administration of a single dose of rosuvastatin (BCRP sub
Eintrag öffnenRydapt · 4.5 · Based on in-vitro data, midostaurin and its active metabolites, CGP52421 and CGP62221, are inhibitors of CYP1A
Eintrag öffnenRydapt · 4.5 · Effect of Rydapt on other medicinal products
Eintrag öffnenRydapt · 4.5 · Effect of other medicinal products on Rydapt
Eintrag öffnenRydapt · 4.5 · Food interactions
Eintrag öffnenRydapt · 4.5 · Hormonal contraceptives There was no clinically significant pharmacokinetic drug-drug interaction between mult
Eintrag öffnenRydapt · 4.5 · In healthy subjects, midostaurin absorption (AUC) was increased by an average of 22% when Rydapt was co-admini
Eintrag öffnenRydapt · 4.5 · Medicinal products or substances known to affect the activity of CYP3A4 may affect the plasma concentrations o
Eintrag öffnenRydapt · 4.5 · Midostaurin undergoes extensive hepatic metabolism mainly through CYP3A4 enzymes which are either induced or i
Eintrag öffnenRydapt · 4.5 · Rydapt is recommended to be administered with food.
Eintrag öffnenRydapt · 4.5 · Strong CYP3A4 inducers Concomitant use of Rydapt with strong inducers of CYP3A4 (e.g. carbamazepine, rifampici
Eintrag öffnenRydapt · 4.5 · Strong CYP3A4 inhibitors Strong CYP3A4 inhibitors may increase midostaurin blood concentrations. In a study wi
Eintrag öffnenRydapt · 4.5 · Substrates of CYP enzymes In healthy subjects, co-administration of a single dose of bupropion (CYP2B6 substra
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