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Tabrecta
Eintrag öffnenTabrecta · 4.1 Therapeutic indications · 1
Eintrag öffnenTabrecta · 4.3 Contraindications · 1
Eintrag öffnenTabrecta · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenTabrecta · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenTabrecta · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenTabrecta · 4.5 · 6 Effect of other medicinal products on Tabrecta
Eintrag öffnenTabrecta · 4.5 · 7 (digoxin, dabigatran etexilate, colchicine, sitagliptin, saxagliptin and posaconazole) or BCRP (methotrexate
Eintrag öffnenTabrecta · 4.5 · Agents that raise gastric pH Capmatinib demonstrates pH-dependent solubility and becomes poorly soluble as pH
Eintrag öffnenTabrecta · 4.5 · Capmatinib undergoes metabolism through CYP3A4 enzyme and aldehyde oxidase. The risk of a drug-drug interactio
Eintrag öffnenTabrecta · 4.5 · Clinically relevant drug-drug interactions between capmatinib and CYP3A substrates are unlikely to occur as co
Eintrag öffnenTabrecta · 4.5 · Effect of Tabrecta on other medicinal products
Eintrag öffnenTabrecta · 4.5 · Moderate CYP3A inducers Simulations using physiologically-based pharmacokinetic (PBPK) models predicted that c
Eintrag öffnenTabrecta · 4.5 · P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) substrates In cancer patients, co-administra
Eintrag öffnenTabrecta · 4.5 · Strong CYP3A inducers In healthy subjects, co-administration of a single 400 mg capmatinib dose with the stron
Eintrag öffnenTabrecta · 4.5 · Strong CYP3A inhibitors In healthy subjects, co-administration of a single 200 mg capmatinib dose with the str
Eintrag öffnenTabrecta · 4.5 · Substrates of CYP enyzmes Moderate inhibition of CYP1A2 was observed when capmatinib was co-administered with
Eintrag öffnenTabrecta · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenTabrecta · 4.8 Undesirable effects · 1
Eintrag öffnenTabrecta · 4.8 · 10 Elevations of pancreatic enzymes Any grade amylase/lipase elevations were reported in 27 of 160 patients (1
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