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Talzenna
Eintrag öffnenTalzenna · 4.1 Therapeutic indications · 1
Eintrag öffnenTalzenna · 4.3 Contraindications · 1
Eintrag öffnenTalzenna · 4.3 · Breast-feeding (see section 4.6).
Eintrag öffnenTalzenna · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenTalzenna · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenTalzenna · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenTalzenna · 4.5 · 6 Agents that may affect talazoparib plasma concentrations
Eintrag öffnenTalzenna · 4.5 · BCRP inhibitors The effect of BCRP inhibitors on PK of talazoparib has not been studied in vivo. Co-administra
Eintrag öffnenTalzenna · 4.5 · Concomitant use of strong P-gp inhibitors (including but not limited to amiodarone, carvedilol, clarithromycin
Eintrag öffnenTalzenna · 4.5 · Effect of acid-reducing agents Population PK analysis indicates that co-administration of acid-reducing agents
Eintrag öffnenTalzenna · 4.5 · Effect of enzalutamide Co-administration with 160 mg enzalutamide increases talazoparib exposure approximately
Eintrag öffnenTalzenna · 4.5 · Effect of other P-gp inhibitors Data from a drug-drug interaction study in patients with advanced solid tumour
Eintrag öffnenTalzenna · 4.5 · P-gp inducers Data from a drug-drug interaction study in patients with advanced solid tumours indicated that c
Eintrag öffnenTalzenna · 4.5 · P-gp inhibitors
Eintrag öffnenTalzenna · 4.5 · Systemic hormonal contraception Drug-drug interaction studies between talazoparib and oral contraceptives have
Eintrag öffnenTalzenna · 4.5 · Talazoparib is a substrate for drug transporters P-gp and breast cancer resistance protein (BCRP) and it is ma
Eintrag öffnenTalzenna · 4.5 · The effect of co-administration of other P-gp inhibitors on talazoparib exposure when talazoparib is given in
Eintrag öffnenTalzenna · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenTalzenna · 4.8 Undesirable effects · 1
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