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Bexaroten
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Eintrag öffnenTargretin · 4.1 Therapeutic indications · 1
Eintrag öffnenTargretin · 4.3 Contraindications · 1
Eintrag öffnenTargretin · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. Pregnancy and lact
Eintrag öffnenTargretin · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenTargretin · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenTargretin · 4.5 · 5 Bexarotene may potentially enhance the action of insulin, agents enhancing insulin secretion (e.g. sulfonylu
Eintrag öffnenTargretin · 4.5 · A population analysis of plasma bexarotene concentrations in patients with CTCL indicated that concomitant adm
Eintrag öffnenTargretin · 4.5 · Caution is advised in case of combination with CYP3A4 substrates having a narrow therapeutic margin i.e. immun
Eintrag öffnenTargretin · 4.5 · Effects of bexarotene on other substances There are indications that bexarotene may induce CYP3A4. Therefore,
Eintrag öffnenTargretin · 4.5 · Effects of other substances on bexarotene No formal studies to evaluate interactions with bexarotene have been
Eintrag öffnenTargretin · 4.5 · Food interactions In all clinical trials, patients were instructed to take Targretin capsules with or immediat
Eintrag öffnenTargretin · 4.5 · Laboratory test interactions CA125 assay values in patients with ovarian cancer may be accentuated with bexaro
Eintrag öffnenTargretin · 4.5 · On the basis of the oxidative metabolism of bexarotene by cytochrome P450 3A4, grapefruit juice may theoretica
Eintrag öffnenTargretin · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenTargretin · 4.8 Undesirable effects · 1
Eintrag öffnenTargretin · 4.8 · 7 System Organ Class Very Common Common Uncommon (MedDRA terminology*) Ear and labyrinth Deafness Ear disorder
Eintrag öffnenTargretin · 4.8 · 8 Newly observed adverse reactions Ecchymosis, petechia, abnormal white blood cells, thromboplastin decreased,
Eintrag öffnenTargretin · 4.8 · Additional adverse reactions observed when used outside of the recommended dose and indication (i.e. used in C
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