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Truqap
Eintrag öffnenTruqap · 4.1 Therapeutic indications · 1
Eintrag öffnenTruqap · 4.3 Contraindications · 1
Eintrag öffnenTruqap · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenTruqap · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenTruqap · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenTruqap · 4.5 · 10 CYP2D6 substrates with a narrow therapeutic index In vitro evaluations indicated that capivasertib has a po
Eintrag öffnenTruqap · 4.5 · CYP2B6 substrates with a narrow therapeutic index In vitro evaluations indicated that capivasertib has a poten
Eintrag öffnenTruqap · 4.5 · Capivasertib is primarily metabolised by CYP3A4 and UGT2B7 enzymes. In vivo, capivasertib is a weak, time-depe
Eintrag öffnenTruqap · 4.5 · Interactions with hepatic transporters (BCRP, OATP1B1, OATP1B3) The exposure of medicinal products that are se
Eintrag öffnenTruqap · 4.5 · Interactions with renal transporters (MATE1, MATE2K, OCT2) The exposure of medicinal products that are sensiti
Eintrag öffnenTruqap · 4.5 · Medicinal products that may decrease capivasertib plasma concentrations
Eintrag öffnenTruqap · 4.5 · Medicinal products that may increase capivasertib plasma concentrations
Eintrag öffnenTruqap · 4.5 · Medicinal products whose plasma concentrations may be altered by capivasertib
Eintrag öffnenTruqap · 4.5 · Moderate CYP3A4 inducers Co-administration of capivasertib with moderate CYP3A4 inducer has the potential to d
Eintrag öffnenTruqap · 4.5 · Moderate CYP3A4 inhibitors Co-administration of TRUQAP with moderate CYP3A4 inhibitors increases capivasertib
Eintrag öffnenTruqap · 4.5 · Strong CYP3A4 inducers Co-administration of TRUQAP with strong CYP3A4 inducers (e.g. carbamazepine, phenytoin,
Eintrag öffnenTruqap · 4.5 · Strong CYP3A4 inhibitors Co-administration of TRUQAP with strong CYP3A4 inhibitors increases capivasertib conc
Eintrag öffnenTruqap · 4.5 · Substrates of CYP3A Concentration of medicinal products that are primarily eliminated via CYP3A metabolism may
Eintrag öffnenTruqap · 4.5 · UGT1A1 substrates with a narrow therapeutic index In vitro evaluations indicated that capivasertib has a poten
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