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Tukysa
Eintrag öffnenTukysa · 4.1 Therapeutic indications · 1
Eintrag öffnenTukysa · 4.3 Contraindications · 1
Eintrag öffnenTukysa · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenTukysa · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenTukysa · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenTukysa · 4.5 · 7 P-gp substrates A clinical drug interaction study found that co-administration of tucatinib with digoxin (a
Eintrag öffnenTukysa · 4.5 · CYP2C8 inhibitors A clinical drug interaction study found that co-administration of a single dose of 300 mg tu
Eintrag öffnenTukysa · 4.5 · CYP2C8 substrates A clinical drug interaction study found that co-administration of tucatinib with repaglinide
Eintrag öffnenTukysa · 4.5 · CYP2C9 substrates Based on clinical drug interaction studies conducted with tucatinib, no drug interactions we
Eintrag öffnenTukysa · 4.5 · CYP3A inhibitors A clinical drug interaction study found that co-administration of a single dose of 300 mg tuc
Eintrag öffnenTukysa · 4.5 · CYP3A substrates Tucatinib is a strong CYP3A inhibitor. A clinical drug interaction study found that co-admini
Eintrag öffnenTukysa · 4.5 · CYP3A/CYP2C8 inducers A clinical drug interaction study found that co-administration of a single dose of 300 m
Eintrag öffnenTukysa · 4.5 · Effects of other medicinal products on tucatinib
Eintrag öffnenTukysa · 4.5 · Effects of tucatinib on other medicinal products
Eintrag öffnenTukysa · 4.5 · MATE1/2K substrates A clinical drug interaction study found that co-administration of tucatinib with metformin
Eintrag öffnenTukysa · 4.5 · Proton pump inhibitors Based on clinical drug interaction studies conducted with tucatinib, no drug interactio
Eintrag öffnenTukysa · 4.5 · Tucatinib is primarily metabolised by CYP2C8. Tucatinib is a metabolism-based inactivator of CYP3A and inhibit
Eintrag öffnenTukysa · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenTukysa · 4.8 Undesirable effects · 1
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