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Azacitidin
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Eintrag öffnenVidaza · 4.1 Therapeutic indications · 1
Eintrag öffnenVidaza · 4.3 Contraindications · 1
Eintrag öffnenVidaza · 4.3 · Advanced malignant hepatic tumours (see section 4.4).
Eintrag öffnenVidaza · 4.3 · Breast-feeding (see section 4.6).
Eintrag öffnenVidaza · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenVidaza · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenVidaza · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenVidaza · 4.5 · 5 No formal clinical drug interaction studies with azacitidine have been conducted.
Eintrag öffnenVidaza · 4.5 · Based on in vitro data, azacitidine metabolism does not appear to be mediated by cytochrome P450 isoenzymes (C
Eintrag öffnenVidaza · 4.5 · Clinically significant inhibitory or inductive effects of azacitidine on cytochrome P450 enzymes are unlikely
Eintrag öffnenVidaza · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenVidaza · 4.8 Undesirable effects · 1
Eintrag öffnenVidaza · 4.8 · 6 thrombocytopenia (2.5%), neutropenia (2.1%), cellulitis (2.1%), dizziness (2.1%) and dyspnoea (2.1%).
Eintrag öffnenVidaza · 4.8 · 7 System Organ Very common Common Uncommon Rare Not Known Class Metabolism and anorexia, decreased dehydration
Eintrag öffnenVidaza · 4.8 · 8 System Organ Very common Common Uncommon Rare Not Known Class General pyrexia*, fatigue, bruising, injection
Eintrag öffnenVidaza · 4.8 · 9 Gastrointestinal adverse reactions The most commonly reported gastrointestinal adverse reactions associated
Eintrag öffnenVidaza · 4.8 · Adult population aged 65 years or older with AML with > 30% marrow blasts The most common serious adverse reac
Eintrag öffnenVidaza · 4.8 · Adult population with MDS, CMML and AML (20-30% marrow blasts) Adverse reactions considered to be possibly or
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