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Begriffe & Kennungen
Crizotinib
Eintrag öffnenXalkori
Eintrag öffnenXalkori · 4.1 Therapeutic indications · 1
Eintrag öffnenXalkori · 4.3 Contraindications · 1
Eintrag öffnenXalkori · 4.3 · Hypersensitivity to crizotinib or to any of the excipients listed in section 6.1.
Eintrag öffnenXalkori · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenXalkori · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenXalkori · 4.5 · 14 Therefore, the concomitant use of strong CYP3A inhibitors (including but not limited to atazanavir, ritonav
Eintrag öffnenXalkori · 4.5 · 15 In vitro studies in human hepatocytes indicated that crizotinib may induce pregnane X receptor (PXR)- and c
Eintrag öffnenXalkori · 4.5 · A starting dose adjustment is not required when crizotinib is coadministered with agents that increase gastric
Eintrag öffnenXalkori · 4.5 · Agents that may decrease crizotinib plasma concentrations Coadministration of repeated doses of crizotinib (25
Eintrag öffnenXalkori · 4.5 · Agents that may increase crizotinib plasma concentrations Coadministration of crizotinib with strong CYP3A inh
Eintrag öffnenXalkori · 4.5 · Agents whose plasma concentrations may be altered by crizotinib Following 28 days of crizotinib dosing at 250
Eintrag öffnenXalkori · 4.5 · Based on an in vitro study, crizotinib is predicted to inhibit intestinal P-gp. Therefore, administration of c
Eintrag öffnenXalkori · 4.5 · Bradycardia has been reported during clinical studies; therefore, use crizotinib with caution due to the risk
Eintrag öffnenXalkori · 4.5 · Coadministration of repeated doses of crizotinib (250 mg once daily) with repeated doses of itraconazole (200
Eintrag öffnenXalkori · 4.5 · Coadministration with medicinal products that increase gastric pH The aqueous solubility of crizotinib is pH d
Eintrag öffnenXalkori · 4.5 · Crizotinib is an inhibitor of OCT1 and OCT2 in vitro. Therefore, crizotinib may have the potential to increase
Eintrag öffnenXalkori · 4.5 · Grapefruit or grapefruit juice may also increase plasma concentrations of crizotinib and should be avoided (se
Eintrag öffnenXalkori · 4.5 · In clinical studies, prolonged QT interval was observed with crizotinib. Therefore, the concomitant use of cri
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