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Natrium-4-Hydroxybutyrat
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Eintrag öffnenXyrem · 4.1 Therapeutic indications · 1
Eintrag öffnenXyrem · 4.3 Contraindications · 1
Eintrag öffnenXyrem · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenXyrem · 4.3 · Patients being treated with opioids or barbiturates.
Eintrag öffnenXyrem · 4.3 · Patients with major depression.
Eintrag öffnenXyrem · 4.3 · Patients with succinic semialdehyde dehydrogenase deficiency.
Eintrag öffnenXyrem · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenXyrem · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenXyrem · 4.5 · 6 Sodium oxybate should not be used in combination with sedative hypnotics or other CNS depressants.
Eintrag öffnenXyrem · 4.5 · 7 pharmacodynamic effects, including increased impairment in cognitive function and sleepiness, were greater w
Eintrag öffnenXyrem · 4.5 · Antidepressants Drug interaction studies in healthy adults demonstrated no pharmacokinetic interactions betwee
Eintrag öffnenXyrem · 4.5 · Diclofenac Drug interaction studies in healthy adults demonstrated no pharmacokinetic interactions between sod
Eintrag öffnenXyrem · 4.5 · GHB dehydrogenase inhibitors Since sodium oxybate is metabolised by GHB dehydrogenase there is a potential ris
Eintrag öffnenXyrem · 4.5 · Ibuprofen Drug interaction studies in healthy adults demonstrated no pharmacokinetic interactions between sodi
Eintrag öffnenXyrem · 4.5 · Modafinil A drug interaction study in healthy adults demonstrated no pharmacokinetic interactions between sodi
Eintrag öffnenXyrem · 4.5 · Omeprazole The co-administration of omeprazole has no clinically significant effect on the pharmacokinetics of
Eintrag öffnenXyrem · 4.5 · Sedative hypnotics Drug interaction studies in healthy adults with sodium oxybate (single dose of 2.25 g) and
Eintrag öffnenXyrem · 4.5 · Studies in vitro with pooled human liver microsomes indicate that sodium oxybate does not significantly inhibi
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