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Yuvanci
Eintrag öffnenYuvanci · 4.1 Therapeutic indications · 1
Eintrag öffnenYuvanci · 4.3 Contraindications · 1
Eintrag öffnenYuvanci · 4.3 · 3 Baseline values of hepatic aminotransferases (aspartate aminotransferases (AST) and/or alanine aminotransf
Eintrag öffnenYuvanci · 4.3 · Hypersensitivity to any of the active substances, or to any of the excipients listed in section 6.1. Acute
Eintrag öffnenYuvanci · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenYuvanci · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenYuvanci · 4.5 · 6 Fluconazole 400 mg daily, a moderate dual inhibitor of CYP3A4 and CYP2C9, may increase exposure to macitenta
Eintrag öffnenYuvanci · 4.5 · 7 Nitrates
Eintrag öffnenYuvanci · 4.5 · Alcohol concentrations were not affected by co-administration with tadalafil (10 mg or 20 mg). In addition, no
Eintrag öffnenYuvanci · 4.5 · Anti-hypertensives (including Calcium channel blockers)
Eintrag öffnenYuvanci · 4.5 · Breast cancer resistance protein (BCRP) substrate drugs: In in vivo studies, macitentan 10 mg once daily did n
Eintrag öffnenYuvanci · 4.5 · CYP1A2 substrates (e.g., theophylline) When tadalafil 10 mg was administered with theophylline (a non-selectiv
Eintrag öffnenYuvanci · 4.5 · CYP2C9 substrates (e.g., R-warfarin) Macitentan given as multiple doses of 10 mg once daily had no effect on e
Eintrag öffnenYuvanci · 4.5 · Co-administration of moderate CYP3A inhibitors Cyclosporine A (100 mg twice daily) a combined CYP3A4 and OATP
Eintrag öffnenYuvanci · 4.5 · Co-administration of moderate CYP3A4 inhibitors with moderate CYP2C9 inhibitors Moderate CYP3A4 inhibitor (e.g
Eintrag öffnenYuvanci · 4.5 · Dual moderate CYP3A4 and CYP2C9 inhibitors Caution should be exercised when Yuvanci is administered concomitan
Eintrag öffnenYuvanci · 4.5 · Effects of Yuvanci on other medicinal products
Eintrag öffnenYuvanci · 4.5 · Effects of other medicinal products on Yuvanci
Eintrag öffnenYuvanci · 4.5 · In clinical studies, riociguat has been shown to augment the hypotensive effects of PDE5 inhibitors. There was
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