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Vemurafenib
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Eintrag öffnenZelboraf · 4.1 Therapeutic indications · 1
Eintrag öffnenZelboraf · 4.3 Contraindications · 1
Eintrag öffnenZelboraf · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenZelboraf · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenZelboraf · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenZelboraf · 4.5 · 8 Caution should be exercised when dosing vemurafenib concurrently with P-gp substrates (e.g. aliskiren, ambri
Eintrag öffnenZelboraf · 4.5 · A clinical drug interaction study demonstrated that multiple oral doses of vemurafenib (960 mg twice daily) in
Eintrag öffnenZelboraf · 4.5 · Co-administration of itraconazole, a strong CYP3A4/Pgp inhibitor, increased steady state vemurafenib AUC by ap
Eintrag öffnenZelboraf · 4.5 · Co-administration of vemurafenib resulted in an 18% increase in AUC of S-warfarin (CYP2C9 substrate). Exercise
Eintrag öffnenZelboraf · 4.5 · Concomitant use of vemurafenib with agents metabolized by CYP1A2 with narrow therapeutic windows (e.g. agomela
Eintrag öffnenZelboraf · 4.5 · Concomitant use of vemurafenib with agents metabolized by CYP3A4 with narrow therapeutic windows is not recomm
Eintrag öffnenZelboraf · 4.5 · Due to the long half-life of vemurafenib, the full inhibitory effect of vemurafenib on a concomitant medicinal
Eintrag öffnenZelboraf · 4.5 · Effects of concomitant medicines on vemurafenib In vitro studies suggest that CYP3A4 metabolism and glucuronid
Eintrag öffnenZelboraf · 4.5 · Effects of vemurafenib on Drug Metabolizing Enzymes Results from an in vivo drug-drug interaction study in met
Eintrag öffnenZelboraf · 4.5 · Effects of vemurafenib on drug transport systems In vitro studies have demonstrated that vemurafenib is an inh
Eintrag öffnenZelboraf · 4.5 · In a clinical study, co-administration of a single dose 960 mg of vemurafenib with rifampicin, significantly d
Eintrag öffnenZelboraf · 4.5 · Mild induction of CYP2B6 by vemurafenib was noted in vitro at a vemurafenib concentration of 10 µM. It is curr
Eintrag öffnenZelboraf · 4.5 · Radiation treatment Potentiation of radiation treatment toxicity has been reported in patients receiving vemur
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