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Zydelig
Eintrag öffnenZydelig · 4.1 Therapeutic indications · 1
Eintrag öffnenZydelig · 4.3 Contraindications · 1
Eintrag öffnenZydelig · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenZydelig · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenZydelig · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenZydelig · 4.5 · 6 Effect of other medicinal products on idelalisib pharmacokinetics
Eintrag öffnenZydelig · 4.5 · 7 Medicinal product Expected effect of Clinical recommendation upon idelalisib on medicinal co-administration
Eintrag öffnenZydelig · 4.5 · 8 Medicinal product Expected effect of Clinical recommendation upon idelalisib on medicinal co-administration
Eintrag öffnenZydelig · 4.5 · 9 Medicinal product Expected effect of Clinical recommendation upon idelalisib on medicinal co-administration
Eintrag öffnenZydelig · 4.5 · Alternative medicinal products, such as olanzapine, may be considered. ENDOTHELIN RECEPTOR ANTAGONISTS Bosenta
Eintrag öffnenZydelig · 4.5 · Atorvastatin ↑ serum concentrations Clinical monitoring is recommended and a lower starting dose of atorvastat
Eintrag öffnenZydelig · 4.5 · BCRP, OATP1B1, OATP1B3 and P-gp substrates Co-administration of multiple doses of idelalisib 150 mg twice dail
Eintrag öffnenZydelig · 4.5 · Bepridil, disopyramide, ↑ serum concentrations Clinical monitoring is recommended. lidocaine ANTI-CANCER AGENT
Eintrag öffnenZydelig · 4.5 · Buspirone, clorazepate, ↑ serum concentrations Concentration monitoring of diazepam, estazolam, sedatives/hypn
Eintrag öffnenZydelig · 4.5 · CYP2C8 substrates In vitro, idelalisib both inhibited and induced CYP2C8, but it is not known whether this tra
Eintrag öffnenZydelig · 4.5 · CYP3A inducers A clinical drug interaction study found that co-administration of a single dose of 150 mg idela
Eintrag öffnenZydelig · 4.5 · CYP3A substrates The primary metabolite of idelalisib, GS-563117, is a strong CYP3A inhibitor. A clinical drug
Eintrag öffnenZydelig · 4.5 · CYP3A/P-gp inhibitors A clinical drug interaction study found that co-administration of a single dose of 400 m
Eintrag öffnenZydelig · 4.5 · Clinical monitoring is recommended for telithromycin.
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