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16 angezeigte Treffer · Seite 1, keine Gesamtzahl für „adagrasib“
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Begriffe & Kennungen
Krazati · 4.5 · 5 to increase oral midazolam AUC by 31-fold. Avoid concomitant use of adagrasib with sensitive CYP3A substrate
Eintrag öffnenKrazati · 4.5 · CYP2C9 substrates: In vitro, adagrasib inhibits CYP2C9. Avoid concomitant use of adagrasib with sensitive CYP2
Eintrag öffnenKrazati · 4.5 · Effects of adagrasib on other medicinal products
Eintrag öffnenKrazati · 4.5 · Effects of other medicinal products on adagrasib
Eintrag öffnenKrazati · 4.5 · In vitro studies showed that adagrasib is metabolised primarily by CYP3A4 and is a reversible inhibitor of CYP
Eintrag öffnenKrazati · 4.5 · P-glycoprotein (P-gp) substrates Administration of adagrasib 600 mg single dose increased digoxin (a P-gp subs
Eintrag öffnenKrazati · 4.5 · Strong CYP3A inhibitors Adagrasib Cmax increased by 2.4-fold and AUC increased by 4-fold following concomitant
Eintrag öffnenKrazati · 4.5 · The effect of co-administration of medicinal products known to prolong the QTc interval with adagrasib is unkn
Eintrag öffnenKrazati · 4.8 · 7 Table 3: Adverse reactions reported in patients treated with adagrasib
Eintrag öffnenKrazati · 4.8 · Adverse reaction frequency estimates are derived from 821 patients exposed at adagrasib 600 mg twice-daily for
Eintrag öffnenKrazati · 4.8 · All subjects treated with adagrasib 600 mg twice daily in clinical studies N = 821 System organ class Frequenc
Eintrag öffnenKrazati · 4.8 · Elderly Adagrasib has been studied in 396 patients aged ≥ 65-year-old. When compared to those < 65 years, no c
Eintrag öffnenMyqorzo · 4.5 · Coadministration of aficamten with more than a single dose of fluconazole and adagrasib is contraindicated (se
Eintrag öffnenMyqorzo · 4.5 · Moderate CYP2C9 inhibitors that Coadministration is are also moderate-to-strong contraindicated for adagrasib
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