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Myqorzo · 4.5 · 7 Table 3: Interactions between aficamten and other medicinal products Medicinal product by mechanism Effects
Eintrag öffnenMyqorzo · 4.5 · 8 Weak CYP2C9 inhibitors that are Caution, adjust the dose of also moderate-to-strong inhibitors aficamten (se
Eintrag öffnenMyqorzo · 4.5 · Aficamten increased total dabigatran exposure by 26% and therefore, aficamten is not a clinically significant
Eintrag öffnenMyqorzo · 4.5 · Aficamten is primarily metabolised by CYP2C9 and, to a lesser extent by CYP2D6 and CYP3A, with minimal CYP2C19
Eintrag öffnenMyqorzo · 4.5 · Coadministration of aficamten is not expected to cause clinically significant drug-drug interactions with sens
Eintrag öffnenMyqorzo · 4.5 · Coadministration of aficamten with medicinal products that are strong inducers of CYP3A and are also moderate
Eintrag öffnenMyqorzo · 4.5 · Coadministration of aficamten with more than a single dose of fluconazole and adagrasib is contraindicated (se
Eintrag öffnenMyqorzo · 4.5 · Effect of aficamten on other medicinal products
Eintrag öffnenMyqorzo · 4.5 · Effect of other medicinal products on aficamten
Eintrag öffnenMyqorzo · 4.5 · Interactions of aficamten and potential co-administered medicinal products are listed in Table 3 below (increa
Eintrag öffnenMyqorzo · 4.8 · In SEQUOIA-HCM study, during the 24-week treatment period, 3.5% patients in the aficamten group experienced a
Eintrag öffnenMyqorzo · 4.8 · In SEQUOIA-HCM, adverse events of hypertension were reported more commonly in the aficamten group compared wit
Eintrag öffnenMyqorzo · 4.8 · The most commonly reported adverse reactions observed with aficamten are dizziness (4.2%), systolic dysfunctio
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