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Erleada · 4.5 · Apalutamide is a potent enzyme inducer and increases the synthesis of many enzymes and transporters; therefore
Eintrag öffnenErleada · 4.5 · Apalutamide is a potent enzyme inducer and increases the synthesis of many enzymes and transporters; therefore
Eintrag öffnenErleada · 4.5 · Apalutamide was shown to be a weak inducer of P-glycoprotein (P-gp), breast cancer resistance protein (BCRP),
Eintrag öffnenErleada · 4.5 · Apalutamide was shown to be a weak inducer of P-glycoprotein (P-gp), breast cancer resistance protein (BCRP),
Eintrag öffnenErleada · 4.5 · CYP2C8 plays a role in the elimination of apalutamide and in the formation of its active metabolite. In a drug
Eintrag öffnenErleada · 4.5 · CYP2C8 plays a role in the elimination of apalutamide and in the formation of its active metabolite. In a drug
Eintrag öffnenErleada · 4.5 · CYP3A4 plays a role in the elimination of apalutamide and in the formation of its active metabolite. In a drug
Eintrag öffnenErleada · 4.5 · CYP3A4 plays a role in the elimination of apalutamide and in the formation of its active metabolite. In a drug
Eintrag öffnenErleada · 4.5 · In humans, apalutamide is a strong inducer of CYP3A4 and CYP2C19, and a weak inducer of CYP2C9. In a drug-drug
Eintrag öffnenErleada · 4.5 · In humans, apalutamide is a strong inducer of CYP3A4 and CYP2C19, and a weak inducer of CYP2C9. In a drug-drug
Eintrag öffnenErleada · 4.5 · In mHSPC subjects receiving leuprolide acetate (a GnRH analogue), co-administration with apalutamide had no ap
Eintrag öffnenErleada · 4.5 · In mHSPC subjects receiving leuprolide acetate (a GnRH analogue), co-administration with apalutamide had no ap
Eintrag öffnenErleada · 4.5 · In vitro studies showed that apalutamide and N-desmethyl apalutamide are moderate to strong CYP3A4 and CYP2B6
Eintrag öffnenErleada · 4.5 · In vitro studies showed that apalutamide and N-desmethyl apalutamide are moderate to strong CYP3A4 and CYP2B6
Eintrag öffnenErleada · 4.5 · Induction of CYP3A4 by apalutamide suggests that UDP-glucuronosyl transferase (UGT) may also be induced via ac
Eintrag öffnenErleada · 4.5 · Induction of CYP3A4 by apalutamide suggests that UDP-glucuronosyl transferase (UGT) may also be induced via ac
Eintrag öffnenErleada · 4.5 · Potential for apalutamide to affect exposures to other medicinal products
Eintrag öffnenErleada · 4.5 · Potential for apalutamide to affect exposures to other medicinal products
Eintrag öffnenErleada · 4.5 · Potential for other medicinal products to affect apalutamide exposures
Eintrag öffnenErleada · 4.5 · Potential for other medicinal products to affect apalutamide exposures
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