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Begriffe & Kennungen
Abatacept
Eintrag öffnenNulojix · 4.5 · Belatacept is a fusion protein that is not expected to be metabolised by the cytochrome P450 enzymes (CYPs) an
Eintrag öffnenNulojix · 4.5 · Belatacept is not expected to interrupt the enterohepatic recirculation of MPA. At a given dose of MMF, MPA ex
Eintrag öffnenNulojix · 4.5 · Immunosuppressant therapy may affect response to vaccination. Therefore, during treatment with belatacept, vac
Eintrag öffnenNulojix · 4.8 · 11 Table 3: Malignancies occurring by treatment group (%) Up to Year 1 Up to Year 3*,** Belatacept Belatacept
Eintrag öffnenNulojix · 4.8 · 12 Within the belatacept clinical program, there were 2 patients diagnosed with PML. One fatal case of PML was
Eintrag öffnenNulojix · 4.8 · A total of 45 of 847 patients (5.3%) developed antibodies during treatment with belatacept. In the individual
Eintrag öffnenNulojix · 4.8 · Adverse reactions resulting in interruption or discontinuation of belatacept in ≥ 1% of patients up to Year 3
Eintrag öffnenNulojix · 4.8 · Conversion Studies 1 and 2 The overall safety profile of belatacept in the two conversion studies was consiste
Eintrag öffnenNulojix · 4.8 · Immunogenicity Antibodies directed against the belatacept molecule were assessed in 796 kidney transplant reci
Eintrag öffnenNulojix · 4.8 · Infections involving the CNS were more frequent in the belatacept MI group (8 cases, including the PML case di
Eintrag öffnenNulojix · 4.8 · The most commonly reported adverse reactions (≥ 20%) among patients treated with both belatacept- based regime
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