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Begriffe & Kennungen
Cannabidiol
Eintrag öffnenEpidyolex · 4.5 · 7 Clobazam When cannabidiol and clobazam are co-administered, bi-directional PK interactions occur. Based on a
Eintrag öffnenEpidyolex · 4.5 · Cannabidiol is a substrate for UGT1A7, UGT1A9 and UGT2B7. No formal drug-drug interaction studies have been co
Eintrag öffnenEpidyolex · 4.5 · Concomitant use of cannabidiol and valproate increases the incidence of diarrhoea and events of decreased appe
Eintrag öffnenEpidyolex · 4.5 · Everolimus Coadministration of cannabidiol (12.5 mg/kg twice daily) with the P-gp and CYP3A4 substrate everoli
Eintrag öffnenEpidyolex · 4.5 · In vitro assessment of interaction with UGT enzymes The metabolite 7-carboxy-cannabidiol (7-COOH-CBD) is an in
Eintrag öffnenEpidyolex · 4.5 · Potential for cannabidiol to affect other medicinal products
Eintrag öffnenEpidyolex · 4.5 · Sensitive CYP2B6 substrates Coadministration of cannabidiol (7.5 mg/kg twice daily) with a single dose of bupr
Eintrag öffnenEpidyolex · 4.5 · Sensitive CYP2C19 substrates In vitro data have demonstrated that cannabidiol inhibits CYP2C19, which may caus
Eintrag öffnenEpidyolex · 4.5 · Sensitive CYP2C9 substrates Coadministration of cannabidiol (7.5 mg/kg twice daily) with a single dose of tolb
Eintrag öffnenEpidyolex · 4.5 · Sensitive P-gp substrates given orally Coadministration of cannabidiol with orally administered everolimus, a
Eintrag öffnenEpidyolex · 4.5 · Sensitive UGT1A9 substrates Coadministration of cannabidiol (7.5 mg/kg twice daily) with a single dose of myco
Eintrag öffnenEpidyolex · 4.5 · Sensitive UGT2B7 substrates Coadministration of cannabidiol (7.5 mg/kg twice daily) with a single dose of zido
Eintrag öffnenEpidyolex · 4.5 · Stiripentol When cannabidiol was combined with stiripentol in a healthy volunteer trial there was an increase
Eintrag öffnenEpidyolex · 4.5 · The pharmacokinetics of cannabidiol are complex and may cause interactions with the patient’s concomitant AED
Eintrag öffnenEpidyolex · 4.5 · Valproate Concomitant use of cannabidiol and valproate increases the incidence of transaminase enzyme elevatio
Eintrag öffnenEpidyolex · 4.8 · Adverse reactions reported with cannabidiol in placebo-controlled clinical studies are listed in the table bel
Eintrag öffnenEpidyolex · 4.8 · Adverse reactions reported with cannabidiol in the recommended dose range of 10 to 25 mg/kg/day are shown belo
Eintrag öffnenEpidyolex · 4.8 · Baseline transaminase elevations In controlled trials (see section 5.1) in patients taking cannabidiol 20 or 2
Eintrag öffnenEpidyolex · 4.8 · Concomitant valproate and clobazam In cannabidiol-treated patients receiving doses of 10, 20, and 25 mg/kg/day
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