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Begriffe zu „carfilzomib“: Kyprolis · 4.5 · Carfilzomib does not inhibit CYP1A2, 2B6, 2C8, 2C9, 2C19 and 2D6 in vitro and is therefore not expected to infKyprolis · 4.5 · Carfilzomib is a P-glycoprotein (P-gp) but not a BCRP substrate. However, given that Kyprolis is administratedKyprolis · 4.5 · Carfilzomib is primarily metabolised via peptidase and epoxide hydrolase activities, and as a result, the pharKyprolis · 4.5 · In vitro studies indicated that carfilzomib did not induce human CYP3A4 in cultured human hepatocytes. A cliniKyprolis · 4.5 · In vitro, carfilzomib inhibits OATP1B1 with an IC50 = 2.01 µM whereas it is unknown whether carfilzomib may or

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