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Cotellic · 4.5 · Avoid concurrent use of strong CYP3A inhibitors during treatment with cobimetinib. Strong CYP3A inhibitors inc
Eintrag öffnenCotellic · 4.5 · Caution should be exercised if cobimetinib is co-administered with moderate CYP3A inhibitors. Moderate CYP3A i
Eintrag öffnenCotellic · 4.5 · Co-administration of cobimetinib with a strong CYP3A inducer was not assessed in a clinical study, however, a
Eintrag öffnenCotellic · 4.5 · Cobimetinib can be co-administered with mild inhibitors of CYP3A without dose adjustment.
Eintrag öffnenCotellic · 4.5 · Cobimetinib is a substrate of P-glycoprotein (P-gp). Concomitant administration of P-gp inhibitors such as cic
Eintrag öffnenCotellic · 4.5 · Cobimetinib is metabolized by CYP3A and cobimetinib AUC increased approximately 7 fold in the presence of a st
Eintrag öffnenCotellic · 4.5 · Effects of cobimetinib on drug transport systems
Eintrag öffnenCotellic · 4.5 · Effects of cobimetinib on other medicinal products
Eintrag öffnenCotellic · 4.5 · Effects of other medicinal products on cobimetinib
Eintrag öffnenCotellic · 4.5 · In vitro studies show that cobimetinib is not a substrate of the liver uptake transporters OATP1B1, OATP1B3 an
Eintrag öffnenCotellic · 4.5 · In vitro, cobimetinib is a moderate inhibitor of BCRP (Breast Cancer Resistance Protein). No clinical DDI stud
Eintrag öffnenCotellic · 4.5 · In vitro, cobimetinib is a potential inducer of CYP1A2 and may therefore reduce the exposure of substrates of
Eintrag öffnenCotellic · 4.5 · There is no evidence of any clinically significant drug-drug interaction between cobimetinib and vemurafenib i
Eintrag öffnenCotellic · 4.8 · ADR frequencies are based upon the safety analysis of patients treated with cobimetinib plus vemurafenib with
Eintrag öffnenCotellic · 4.8 · Changes in reported Cobimetinib plus Placebo plus vemurafenib laboratory data vemurafenib (n = 246) (n = 247)
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