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Finlee · 4.5 · 11 Effect of dabrafenib on other medicinal products
Eintrag öffnenFinlee · 4.5 · 12 Effects of dabrafenib on substance transport systems
Eintrag öffnenFinlee · 4.5 · Administration of dabrafenib and warfarin resulted in a decrease in AUC of S- and R-warfarin of 37% and 33%, r
Eintrag öffnenFinlee · 4.5 · Administration of gemfibrozil (a CYP2C8 inhibitor) 600 mg twice daily, with dabrafenib 75 mg twice daily, resu
Eintrag öffnenFinlee · 4.5 · Administration of ketoconazole (a CYP3A4 inhibitor) 400 mg once daily, with dabrafenib 75 mg twice daily, resu
Eintrag öffnenFinlee · 4.5 · Administration of rifampin (a CYP3A4/CYP2C8 inducer) 600 mg once daily, with dabrafenib 150 mg twice daily, re
Eintrag öffnenFinlee · 4.5 · Co-administration of repeat doses of dabrafenib 150 mg twice daily and the pH-elevating agent rabeprazole 40 m
Eintrag öffnenFinlee · 4.5 · Dabrafenib is a substrate for the metabolising enzymes CYP2C8 and CYP3A4, while the active metabolites hydroxy
Eintrag öffnenFinlee · 4.5 · Dabrafenib is an enzyme inducer and increases the synthesis of drug-metabolising enzymes including CYP3A4, CYP
Eintrag öffnenFinlee · 4.5 · Dabrafenib is an in vitro inhibitor of human organic anion transporting polypeptide (OATP) 1B1 (OATP1B1), OATP
Eintrag öffnenFinlee · 4.5 · Effect of other medicinal products on dabrafenib
Eintrag öffnenFinlee · 4.5 · In vitro, dabrafenib is a mechanism based inhibitor of CYP3A4. Therefore, transient inhibition of CYP3A4 may b
Eintrag öffnenFinlee · 4.5 · In vitro, dabrafenib produced dose-dependent increases in CYP2B6 and CYP3A4. In a clinical drug interaction st
Eintrag öffnenFinlee · 4.5 · Onset of induction is likely to occur after 3 days of repeat dosing with dabrafenib. Upon discontinuation of d
Eintrag öffnenFinlee · 4.8 · Cutaneous malignancies In the integrated adult safety population for dabrafenib in combination with trametinib
Eintrag öffnenFinlee · 4.8 · In clinical studies of paediatric patients treated with dabrafenib in combination with trametinib, the most co
Eintrag öffnenFinlee · 4.8 · Pyrexia Fever has been reported in clinical studies with dabrafenib in combination with trametinib (see sectio
Eintrag öffnenFinlee · 4.8 · Table 4 Adverse reactions with dabrafenib in combination with trametinib
Eintrag öffnenFinlee · 4.8 · The safety of dabrafenib in combination with trametinib has been evaluated in a pooled safety set of 171 paedi
Eintrag öffnenGhryvelin (previously Macimorelin Aeterna Zentaris) · 4.5 · Administration of a CYP3A4 inducer (such as carbamazepine, dabrafenib, efavirenz, enzalutamide, eslicarbazepin
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