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Busulfan Fresenius Kabi · 4.5 · Increases in busulfan exposure have been observed at concomitant administration of busulfan and deferasirox. T
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Eintrag öffnenDeferasirox Accord · 4.1 Therapeutic indications · 1
Eintrag öffnenDeferasirox Accord · 4.3 Contraindications · 1
Eintrag öffnenDeferasirox Accord · 4.3 · Combination with other iron chelator therapies as the safety of such combinations has not been established (se
Eintrag öffnenDeferasirox Accord · 4.3 · Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Eintrag öffnenDeferasirox Accord · 4.3 · Patients with estimated creatinine clearance <60 ml/min.
Eintrag öffnenDeferasirox Accord · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenDeferasirox Accord · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenDeferasirox Accord · 4.5 · 11 deferasirox with repaglinide should be avoided. If the combination appears necessary, careful clinical and
Eintrag öffnenDeferasirox Accord · 4.5 · Agents that may decrease deferasirox systemic exposure
Eintrag öffnenDeferasirox Accord · 4.5 · Cholestyramine significantly reduced the deferasirox exposure in a mechanistic study to determine the degree o
Eintrag öffnenDeferasirox Accord · 4.5 · Concomitant administration of deferasirox and busulfan resulted in an increase of busulfan exposure (AUC), but
Eintrag öffnenDeferasirox Accord · 4.5 · Deferasirox metabolism depends on UGT enzymes. In a healthy volunteer study, the concomitant administration of
Eintrag öffnenDeferasirox Accord · 4.5 · In a healthy volunteer study, the concomitant administration of deferasirox as a CYP1A2 inhibitor (repeated do
Eintrag öffnenDeferasirox Accord · 4.5 · In a healthy volunteer study, the concomitant administration of deferasirox as a moderate CYP2C8 inhibitor (30
Eintrag öffnenDeferasirox Accord · 4.5 · In a healthy volunteer study, the concomitant administration of deferasirox dispersible tablets and midazolam
Eintrag öffnenDeferasirox Accord · 4.5 · Interaction with food
Eintrag öffnenDeferasirox Accord · 4.5 · Interaction with midazolam and other agents metabolised by CYP3A4
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