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Phenothiazin‑Antipsychotika Differenzialdiagnostik & Therapie‑Standard (T43.3)

Antipsychotika und Neuroleptika auf Phenothiazin‑Basis bilden eine heterogene Gruppe von Wirkstoffen, die primär als Dopamin‑D2‑Rezeptor‑Antagonisten in der Behandlung psychotischer Störungen eingesetzt werden. Neben ihrer psychiatrischen …

ATP-binding Cassette Transporter 1

Akynzeo · 4.5 · In vitro data suggests that netupitant inhibits the efflux of transporter BCRP. The clinical relevance of this

Akynzeo · 4.5 · Inhibition of the efflux transported BCRP and glucuronidation isozyme UGT2B7 by netupitant and its metabolites

Alecensa · 4.5 · Breast cancer resistance protein (BCRP) substrates In vitro, alectinib and M4 are inhibitors of the efflux tra

Alecensa · 4.5 · P-gp substrates In vitro, alectinib and its major active metabolite M4 are inhibitors of the efflux transporte

Ambrisentan Viatris (previously Ambrisentan Mylan) · 4.5 · Ambrisentan is a substrate for Pgp-mediated efflux.

Repurposing Antidepressants and Phenothiazine Antipsychotics as Efflux Pump Inhibitors in Cancer and Infectious Diseases

pubmed · 36671340

JIP4 deficiency causes a lysosomal storage disease arising from impaired cystine efflux

doi · 10.1101/2025.06.06.657909