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Doptelet · 4.5 · Concomitant use of moderate or strong CYP3A4/5 and CYP2C9 dual inducers (e.g., rifampicin, enzalutamide) reduc
Eintrag öffnenEnzalutamide Viatris
Eintrag öffnenEnzalutamide Viatris · 4.1 Therapeutic indications · 1
Eintrag öffnenEnzalutamide Viatris · 4.3 Contraindications · 1
Eintrag öffnenEnzalutamide Viatris · 4.3 · • Hypersensitivity to the active substance(s) or to any of the excipients listed in section 6.1. • Women who a
Eintrag öffnenEnzalutamide Viatris · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenEnzalutamide Viatris · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenEnzalutamide Viatris · 4.5 · 6 Interactions with certain medicinal products that are eliminated through metabolism or active transport are
Eintrag öffnenEnzalutamide Viatris · 4.5 · 7 Falsely elevated digoxin plasma level results with the chemiluminescent microparticle immunoassay (CMIA) hav
Eintrag öffnenEnzalutamide Viatris · 4.5 · BCRP substrates At steady-state, enzalutamide did not cause a clinically meaningful change in exposure to the
Eintrag öffnenEnzalutamide Viatris · 4.5 · CYP1A2 and CYP2C8 substrates Enzalutamide (160 mg once daily) did not cause a clinically relevant change in th
Eintrag öffnenEnzalutamide Viatris · 4.5 · CYP2C8 and CYP3A4 inducers Following oral administration of the moderate CYP2C8 and strong CYP3A4 inducer rifa
Eintrag öffnenEnzalutamide Viatris · 4.5 · CYP2C8 inhibitors CYP2C8 plays an important role in the elimination of enzalutamide and in the formation of it
Eintrag öffnenEnzalutamide Viatris · 4.5 · CYP3A4 inhibitors CYP3A4 plays a minor role in the metabolism of enzalutamide. Following oral administration o
Eintrag öffnenEnzalutamide Viatris · 4.5 · Effect of food on enzalutamide exposures
Eintrag öffnenEnzalutamide Viatris · 4.5 · Enzyme induction Enzalutamide is a potent enzyme inducer and increases the synthesis of many enzymes and trans
Eintrag öffnenEnzalutamide Viatris · 4.5 · Food has no clinically significant effect on the extent of exposure to enzalutamide. In clinical trials, enzal
Eintrag öffnenEnzalutamide Viatris · 4.5 · Groups of medicinal products that can be affected include, but are not limited to: • Analgesics (e.g. fentanyl
Eintrag öffnenEnzalutamide Viatris · 4.5 · In vivo studies have shown that enzalutamide is a strong inducer of CYP3A4 and a moderate inducer of CYP2C9 an
Eintrag öffnenEnzalutamide Viatris · 4.5 · Laboratory Test Interference
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