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Jyseleca · 4.5 · Effect of filgotinib on other medicinal products
Eintrag öffnenJyseleca · 4.5 · Effect of other medicinal products on filgotinib
Eintrag öffnenJyseleca · 4.5 · Filgotinib is not a clinically relevant inhibitor or inducer of most enzymes or transporters commonly involved
Eintrag öffnenJyseleca · 4.5 · Filgotinib is primarily metabolised by carboxylesterase 2 (CES2), which can be inhibited in vitro by medicinal
Eintrag öffnenJyseleca · 4.5 · In vitro studies are inconclusive regarding the potential of filgotinib to induce CYP2B6. In vivo induction ca
Eintrag öffnenJyseleca · 4.5 · In vitro studies are inconclusive regarding the potential of filgotinib to induce or inhibit CYP1A2. No clinic
Eintrag öffnenJyseleca · 4.8 · Creatinine An increase in serum creatinine occurred with filgotinib treatment. At week 24 in the Phase 3 studi
Eintrag öffnenJyseleca · 4.8 · Lipids Treatment with filgotinib was associated with dose-dependent increases in total cholesterol and HDL lev
Eintrag öffnenJyseleca · 4.8 · Nausea Nausea was generally transient and reported during the first 24 weeks of filgotinib treatment.
Eintrag öffnenJyseleca · 4.8 · Ulcerative colitis In general, the overall safety profile observed in filgotinib-treated patients with ulcerat
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