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Idelalisib
Eintrag öffnenZydelig · 4.5 · 6 Effect of other medicinal products on idelalisib pharmacokinetics
Eintrag öffnenZydelig · 4.5 · 7 Medicinal product Expected effect of Clinical recommendation upon idelalisib on medicinal co-administration
Eintrag öffnenZydelig · 4.5 · 8 Medicinal product Expected effect of Clinical recommendation upon idelalisib on medicinal co-administration
Eintrag öffnenZydelig · 4.5 · 9 Medicinal product Expected effect of Clinical recommendation upon idelalisib on medicinal co-administration
Eintrag öffnenZydelig · 4.5 · BCRP, OATP1B1, OATP1B3 and P-gp substrates Co-administration of multiple doses of idelalisib 150 mg twice dail
Eintrag öffnenZydelig · 4.5 · CYP2C8 substrates In vitro, idelalisib both inhibited and induced CYP2C8, but it is not known whether this tra
Eintrag öffnenZydelig · 4.5 · CYP3A substrates The primary metabolite of idelalisib, GS-563117, is a strong CYP3A inhibitor. A clinical drug
Eintrag öffnenZydelig · 4.5 · Effect of idelalisib on the pharmacokinetics of other medicinal products
Eintrag öffnenZydelig · 4.5 · Idelalisib is metabolised primarily via aldehyde oxidase, and to a lesser extent via CYP3A and glucuronidation
Eintrag öffnenZydelig · 4.5 · Medicinal product Expected effect of Clinical recommendation upon idelalisib on medicinal co-administration wi
Eintrag öffnenZydelig · 4.5 · Potential interactions between idelalisib and co-administered medicinal products that are CYP3A substrates are
Eintrag öffnenZydelig · 4.5 · Sildenafil ↑ serum concentrations Idelalisib should not be co-administered with sildenafil.
Eintrag öffnenZydelig · 4.5 · Substrates of inducible enzymes (e.g., CYP2C9, CYP2C19, CYP2B6 and UGT) In vitro, idelalisib was an inducer of
Eintrag öffnenZydelig · 4.5 · Table 1: Interactions between idelalisib and other medicinal products that are CYP3A substrates
Eintrag öffnenZydelig · 4.8 · 11 and 136 subjects who received idelalisib in combination with an anti-CD20 monoclonal antibody (rituximab or
Eintrag öffnenZydelig · 4.8 · In clinical studies of subjects with hematologic malignancies who received idelalisib, the most frequently rep
Eintrag öffnenZydelig · 4.8 · Severe cutaneous reactions (see section 4.4) Cases of SJS, TEN and DRESS have occurred when idelalisib was adm
Eintrag öffnenZydelig · 4.8 · The adverse drug reactions reported with idelalisib alone or in combination with anti-CD20 monoclonal antibodi
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