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Lazcluze · 4.5 · Agents that may alter lazertinib plasma concentrations
Eintrag öffnenLazcluze · 4.5 · No clinically relevant differences in lazertinib pharmacokinetics were observed when co-administered with gast
Eintrag öffnenLazcluze · 4.5 · Strong CYP3A4 inducers can decrease lazertinib plasma concentrations. Lazertinib may increase the plasma conce
Eintrag öffnenLazcluze · 4.5 · The co-administration of multiple doses of itraconazole (strong CYP3A4 inhibitor) increased lazertinib Cmax by
Eintrag öffnenLazcluze · 4.5 · The co-administration of multiple doses of rifampicin (strong CYP3A4 inducer) decreased lazertinib Cmax by 72%
Eintrag öffnenLazcluze · 4.8 · Diarrhoea occurred in 29% of patients treated with lazertinib in combination with amivantamab. Most events wer
Eintrag öffnenLazcluze · 4.8 · Eye disorders, including keratitis (2.6%), occurred in patients treated with lazertinib in combination with am
Eintrag öffnenLazcluze · 4.8 · Hepatotoxicity-related reactions occurred in 47% of patients treated with lazertinib in combination with amiva
Eintrag öffnenLazcluze · 4.8 · In patients receiving lazertinib in combination with amivantamab, the median time to first onset of a VTE even
Eintrag öffnenLazcluze · 4.8 · Paraesthesia occurred in 34% of patients treated with lazertinib in combination with amivantamab. Most events
Eintrag öffnenLazcluze · 4.8 · Stomatitis occurred in 43% of patients treated with lazertinib in combination with amivantamab. Most events we
Eintrag öffnenLazcluze · 4.8 · Table 3 summarises the adverse reactions that occurred in patients receiving lazertinib in combination with am
Eintrag öffnenLazcluze · 4.8 · Table 3: Adverse reactions in patients receiving lazertinib in combination with amivantamab System organ class
Eintrag öffnenLazcluze · 4.8 · The data reflects exposure to lazertinib in 421 patients who received lazertinib in combination with amivantam
Eintrag öffnenLazcluze · 4.8 · There are limited clinical data with lazertinib in patients 75 years of age or over (see section 5.1). Older p
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