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17 angezeigte Treffer · Seite 1, keine Gesamtzahl für „leniolisib“
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Begriffe & Kennungen
Joenja · 4.5 · BCRP inhibitors Leniolisib is a substrate of BCRP transporters. No interaction studies have been conducted wit
Eintrag öffnenJoenja · 4.5 · CYP3A4 inducers No interaction studies have been conducted with leniolisib and strong and moderate CYP3A4 indu
Eintrag öffnenJoenja · 4.5 · CYP3A4 inhibitors Leniolisib is cleared primarily through oxidative metabolism (primarily hydroxylation and de
Eintrag öffnenJoenja · 4.5 · Gastric acid reducing agents Leniolisib exhibits pH-dependent solubility, with lower solubility at higher pH-v
Eintrag öffnenJoenja · 4.5 · Hormonal contraceptives Administration of leniolisib with a single dose oral contraceptive containing ethinyle
Eintrag öffnenJoenja · 4.5 · Medicinal products affecting the pharmacokinetics of leniolisib
Eintrag öffnenJoenja · 4.5 · Medicinal products that have their exposure altered by leniolisib
Eintrag öffnenJoenja · 4.5 · OAT3 substrates Leniolisib is an OAT3 inhibitor and may increase systemic exposure to OAT3 substrates (e.g., a
Eintrag öffnenJoenja · 4.5 · OATP1B1, OATP1B3, and BCRP substrates When co-administered, leniolisib increased rosuvastatin exposure 2-fold.
Eintrag öffnenJoenja · 4.5 · UDP-glucuronosyltransferase (UGT) 1A1 substrates In vitro, leniolisib is an inhibitor of UGT1A1, and although
Eintrag öffnenJoenja · 4.8 · Neutrophil count decreased Seven (33%) patients receiving leniolisib developed a transient absolute neutrophil
Eintrag öffnenJoenja · 4.8 · The most commonly reported adverse reactions during leniolisib treatment were headache (32%), vomiting (16%),
Eintrag öffnenJoenja · 4.8 · The safety of leniolisib was evaluated in 38 adolescent and adult patients with APDS who participated in the p
Eintrag öffnenJoenja · 4.8 · Thirteen patients aged 12 to 17 were treated with leniolisib in the clinical trials. Frequency, type, and seve
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Eintrag öffnenleniolisib phosphate
Eintrag öffnenleniolisib phosphate
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