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Pyrukynd · 4.5 · CYP3A4 substrates The effect of mitapivat (100 mg twice daily) on the pharmacokinetics of a single dose of mid
Eintrag öffnenPyrukynd · 4.5 · CYP3A4 substrates The effect of mitapivat (100 mg twice daily) on the pharmacokinetics of a single dose of mid
Eintrag öffnenPyrukynd · 4.5 · Effect of mitapivat on other medicinal products
Eintrag öffnenPyrukynd · 4.5 · Effect of mitapivat on other medicinal products
Eintrag öffnenPyrukynd · 4.5 · Effects of other medicinal products on mitapivat
Eintrag öffnenPyrukynd · 4.5 · Effects of other medicinal products on mitapivat
Eintrag öffnenPyrukynd · 4.5 · Gastric acid-reducing agents Concomitant use of mitapivat with medicinal products that elevate gastric pH was
Eintrag öffnenPyrukynd · 4.5 · Gastric acid-reducing agents Mitapivat exhibits pH-dependent solubility (see section 5.2) and coadministration
Eintrag öffnenPyrukynd · 4.5 · Hormonal contraceptives Mitapivat may alter the systemic exposure of hormonal contraceptives that are sensitiv
Eintrag öffnenPyrukynd · 4.5 · Hormonal contraceptives Mitapivat may alter the systemic exposure of hormonal contraceptives that are sensitiv
Eintrag öffnenPyrukynd · 4.5 · Mitapivat is primarily metabolised by CYP3A4 and is a substrate for P-glycoprotein (P-gp). Mitapivat induces C
Eintrag öffnenPyrukynd · 4.5 · Mitapivat is primarily metabolised by CYP3A4 and is a substrate for P-glycoprotein (P-gp). Mitapivat induces C
Eintrag öffnenPyrukynd · 4.5 · P-gp substrates Based on in vitro data, mitapivat may induce and inhibit P-gp (see section 5.2) and may alter
Eintrag öffnenPyrukynd · 4.5 · P-gp substrates Based on in vitro data, mitapivat may induce and inhibit P-gp (see section 5.2) and may alter
Eintrag öffnenPyrukynd · 4.5 · UGT1A1, CYP2B6 and CYP2C substrates Based on in vitro data, mitapivat may induce UGT1A1, CYP2B6, CYP2C8, CYP2C
Eintrag öffnenPyrukynd · 4.5 · UGT1A1, CYP2B6 and CYP2C substrates Based on in vitro data, mitapivat may induce UGT1A1, CYP2B6, CYP2C8, CYP2C
Eintrag öffnenPyrukynd · 4.8 · Changes in sex hormone levels Mitapivat is a weak aromatase inhibitor in vitro. In ACTIVATE, 1 of 16 (6.3%) ma
Eintrag öffnenPyrukynd · 4.8 · Changes in sex hormone levels Mitapivat is a weak aromatase inhibitor in vitro. In ENERGIZE, 15 of 46 (32.6%)
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