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20 angezeigte Treffer · Seite 1, keine Gesamtzahl für „nilotinib“
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Norvir · 4.5 · Dasatinib, nilotinib, vincristine, Serum concentrations may be increased when co-administered with ritonavir r
Eintrag öffnenNorvir · 4.5 · Dasatinib, nilotinib, vincristine, Serum concentrations may be increased when co-administered with ritonavir v
Eintrag öffnenTasigna · 4.5 · 10 The exposure to nilotinib in healthy subjects was increased 3-fold when co-administered with the strong CYP
Eintrag öffnenTasigna · 4.5 · Concomitant administration of nilotinib with imatinib (a substrate and moderator of P-gp and CYP3A4), had a sl
Eintrag öffnenTasigna · 4.5 · In CML patients, nilotinib administered at 400 mg twice daily for 12 days increased the systemic exposure (AUC
Eintrag öffnenTasigna · 4.5 · In a study in healthy subjects, no significant change in nilotinib pharmacokinetics was observed when a single
Eintrag öffnenTasigna · 4.5 · In vitro, nilotinib is a relatively strong inhibitor of CYP3A4, CYP2C8, CYP2C9, CYP2D6 and UGT1A1, with Ki val
Eintrag öffnenTasigna · 4.5 · Nilotinib has pH dependent solubility, with lower solubility at higher pH. In healthy subjects receiving esome
Eintrag öffnenTasigna · 4.5 · Nilotinib is mainly metabolised in the liver with CYP3A4 expected to be the main contributor to the oxidative
Eintrag öffnenTasigna · 4.5 · Nilotinib should be used with caution in patients who have or may develop prolongation of the QT interval, inc
Eintrag öffnenTasigna · 4.5 · Rifampicin, a potent CYP3A4 inducer, decreases nilotinib Cmax by 64% and reduces nilotinib AUC by 80%. Rifampi
Eintrag öffnenTasigna · 4.5 · Substances that may decrease nilotinib serum concentrations
Eintrag öffnenTasigna · 4.5 · Substances that may have their systemic concentration altered by nilotinib
Eintrag öffnenTasigna · 4.5 · Substances that may increase nilotinib serum concentrations
Eintrag öffnenTasigna · 4.5 · The absorption and bioavailability of nilotinib are increased if it is taken with food, resulting in a higher
Eintrag öffnenTasigna · 4.5 · The combination of nilotinib with those statins that are mainly eliminated by CYP3A4, may increase the potenti
Eintrag öffnenTasigna · 4.8 · The safety of nilotinib in paediatric patients (from 2 to <18 years of age) with Philadelphia chromosome posit
Eintrag öffnenTasigna · 4.8 · The safety profile of nilotinib is consistent across indications.
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