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17 angezeigte Treffer · Seite 1, keine Gesamtzahl für „nirogacestat“
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Ogsiveo · 4.5 · Agents that may decrease nirogacestat serum concentrations
Eintrag öffnenOgsiveo · 4.5 · Agents that may increase nirogacestat serum concentrations
Eintrag öffnenOgsiveo · 4.5 · Drug transporter systems A single-dose drug‑drug interaction study demonstrated that nirogacestat did not affe
Eintrag öffnenOgsiveo · 4.5 · Effect of acid‑reducing agents Nirogacestat has pH‑dependent solubility, with substantially reduced solubility
Eintrag öffnenOgsiveo · 4.5 · Effect of strong and moderate CYP3A4 inducers The effects of CYP3A4 inducers on nirogacestat exposure have not
Eintrag öffnenOgsiveo · 4.5 · Effects of nirogacestat on the pharmacokinetics of other medicinal products
Eintrag öffnenOgsiveo · 4.5 · In vitro studies showed that nirogacestat may induce CYP2C8, CYP2C9, CYP2C19, and CYP2B6 and thus there is a r
Eintrag öffnenOgsiveo · 4.5 · Nirogacestat is primarily metabolized by CYP3A4 and is a substrate of P‑glycoprotein (P-gp).
Eintrag öffnenOgsiveo · 4.5 · Since no study has been performed investigating the effect of nirogacestat on systemic contraceptive steroid e
Eintrag öffnenOgsiveo · 4.8 · 10 (range 4 to 18 weeks). Effects of nirogacestat on fertility are unknown (see section 4.4). An exposure- res
Eintrag öffnenOgsiveo · 4.8 · 8 Permanent discontinuation of nirogacestat due to an adverse event occurred in 19% of patients. The most comm
Eintrag öffnenOgsiveo · 4.8 · Electrolyte abnormalities Electrolyte abnormalities were reported in patients receiving nirogacestat in the do
Eintrag öffnenOgsiveo · 4.8 · The frequency of dose interruption of nirogacestat due to adverse reactions was 59%. The most common adverse r
Eintrag öffnenOgsiveo · 4.8 · The frequency of dose reduction of nirogacestat due to adverse reactions was 44%. The most common adverse reac
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