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Farydak · 4.5 · 11 Agents that are predicted to decrease panobinostat concentrations
Eintrag öffnenFarydak · 4.5 · Agents that may increase panobinostat plasma concentrations
Eintrag öffnenFarydak · 4.5 · Agents whose plasma concentrations may be increased by panobinostat
Eintrag öffnenFarydak · 4.5 · Agents whose plasma exposure can be decreased by panobinostat
Eintrag öffnenFarydak · 4.5 · Co-administration of a single 20 mg panobinostat dose with ketoconazole, a strong CYP3A inhibitor, increased t
Eintrag öffnenFarydak · 4.5 · Farydak metabolism is through both non-CYP and CYP mediated routes. Approximately 40% of panobinostat is metab
Eintrag öffnenFarydak · 4.5 · Hormonal contraceptives It is currently unknown whether panobinostat may reduce the effectiveness of hormonal
Eintrag öffnenFarydak · 4.5 · No data is available that can be used to exclude the risk that panobinostat could be a weak inducer of the enz
Eintrag öffnenFarydak · 4.5 · Panobinostat increased the Cmax and the AUC of dextromethorphan (a substrate of CYP2D6) by 1.8- and 1.6-fold,
Eintrag öffnenFarydak · 4.5 · Prolongation of QT interval Based on preclinical and clinical data, panobinostat has the potential to prolong
Eintrag öffnenFarydak · 4.5 · The panobinostat fraction metabolised through CYP3A4 is approximately 40%. In clinical studies in multiple mye
Eintrag öffnenFarydak · 4.8 · ECG (electrocardiogram) abnormalities have been reported in patients treated with panobinostat + bortezomib +
Eintrag öffnenFarydak · 4.8 · On-treatment deaths not due to the study indication (multiple myeloma) were reported in 6.8% of panobinostat +
Eintrag öffnenFarydak · 4.8 · Table 7 Panobinostat adverse drug reactions observed in multiple myeloma patients in the phase III study
Eintrag öffnenFarydak · 4.8 · Table 7 includes adverse drug reactions that occur due to the addition of panobinostat to the bortezomib and d
Eintrag öffnenFarydak · 4.8 · The safety data of panobinostat have been assessed from a total of 451 patients with multiple myeloma treated
Eintrag öffnenFarydak · 4.8 · Thrombocytopenia Due to the nature of multiple myeloma and the known haematotoxicity for panobinostat and its
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