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Begriffe zu „pazopanib“: Votrient · 4.5 · 8 once daily alone. Some patients however may have systemic pazopanib exposure greater than what has been obseVotrient · 4.5 · 9 Pazopanib is an inhibitor of the uridine diphosphoglucuronosyl-transferase 1A1 (UGT1A1) enzyme in vitro. TheVotrient · 4.5 · Administration of pazopanib with a high-fat or low-fat meal results in an approximately 2-fold increase in AUCVotrient · 4.5 · Based on in vitro IC50 and in vivo plasma Cmax values, pazopanib metabolites GSK1268992 and GSK1268997 may conVotrient · 4.5 · CYP3A4, P-gp, BCRP inducers CYP3A4 inducers such as rifampin may decrease plasma pazopanib concentrations. Co-

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