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Begriffe zu „regorafenib“: Stivarga · 4.5 · 8 The concentration-time profile indicates that regorafenib and its metabolites may undergo enterohepatic circStivarga · 4.5 · Administration of rifampicin (600 mg for 9 days), a strong CYP3A4 inducer, with a single dose of regorafenib (Stivarga · 4.5 · Bile salt-sequestering agents Regorafenib, M-2 and M-5 are likely to undergo enterohepatic circulation (see seStivarga · 4.5 · Breast cancer resistance protein (BCRP) and P-glycoprotein substrates Administration of regorafenib (160 mg foStivarga · 4.5 · CYP isoform-selective substrates In vitro data indicate that regorafenib is a competitive inhibitor of the cyt

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