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Begriffe & Kennungen
Wayrilz · 4.5 · 5 observed in rilzabrutinib exposure if rilzabrutinib was administered at least 2 hours prior to famotidine.
Eintrag öffnenWayrilz · 4.5 · After co-administration of rilzabrutinib with a strong P-gp inhibitor (quinidine), a modest increase in exposu
Eintrag öffnenWayrilz · 4.5 · Agents that may decrease rilzabrutinib plasma concentrations
Eintrag öffnenWayrilz · 4.5 · Agents that may have their plasma concentrations altered by rilzabrutinib
Eintrag öffnenWayrilz · 4.5 · Agents that may increase rilzabrutinib plasma concentrations
Eintrag öffnenWayrilz · 4.5 · Avoid co-administration of rilzabrutinib with PPIs. If treatment with a gastric acid reducing agent is require
Eintrag öffnenWayrilz · 4.5 · Avoid co-administration of rilzabrutinib with moderate or strong CYP3A inducers (e.g., carbamazepine, rifampic
Eintrag öffnenWayrilz · 4.5 · Co-administration of rilzabrutinib with a moderate or strong CYP3A inhibitor increases rilzabrutinib plasma co
Eintrag öffnenWayrilz · 4.5 · Co-administration of rilzabrutinib with moderate or strong CYP3A inducers decreases rilzabrutinib plasma conce
Eintrag öffnenWayrilz · 4.5 · Co-administration with a strong CYP3A inducer (rifampicin) decreased rilzabrutinib Cmax and AUC by about 80% i
Eintrag öffnenWayrilz · 4.5 · Co-administration with a strong CYP3A inhibitor (ritonavir) increased the rilzabrutinib Cmax by approximately
Eintrag öffnenWayrilz · 4.5 · Rilzabrutinib has shown potential to inhibit the P-gp, BCRP, and OATP1B3 transporters in vitro. There is a pos
Eintrag öffnenWayrilz · 4.5 · Rilzabrutinib is both an in vitro inhibitor and inducer of the CYP3A4 enzyme. Co-administration of a single 40
Eintrag öffnenWayrilz · 4.5 · Rilzabrutinib is primarily metabolized by CYP3A.
Eintrag öffnenWayrilz · 4.5 · Rilzabrutinib solubility decreases with increasing pH. Co-administration with a PPI (esomeprazole) decreased r
Eintrag öffnenWayrilz · 4.5 · The effect of rilzabrutinib on the plasma concentrations of hormonal contraceptives is unknown. Therefore, wom
Eintrag öffnenWayrilz · 4.8 · Elderly Among the patients exposed to rilzabrutinib (n=284), 51 (17.9%) patients were 65 years of age or older
Eintrag öffnenWayrilz · 4.8 · Gastrointestinal disorders Among patients exposed to rilzabrutinib, the most common GI adverse reactions were
Eintrag öffnenWayrilz · 4.8 · Infections Among patients exposed to rilzabrutinib, the most common infection adverse reactions were COVID- 19
Eintrag öffnenWayrilz · 4.8 · Rash Among patients exposed to rilzabrutinib, rash (including rash maculo-papular, rash papular, rash erythema
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