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Mayzent · 4.5 · CYP2C9 and CYP3A4 inducers Siponimod may be combined with most types of CYP2C9 and CYP3A4 inducers. However, b
Eintrag öffnenMayzent · 4.5 · CYP2C9 inhibitors Concomitant use of siponimod and medicinal products that cause moderate or strong CYP2C9 inh
Eintrag öffnenMayzent · 4.5 · Caution should be exercised when siponimod is initiated in patients receiving beta blockers due to the additiv
Eintrag öffnenMayzent · 4.5 · Co-administration with siponimod did not reveal clinically relevant effects on the pharmacokinetics and pharma
Eintrag öffnenMayzent · 4.5 · Cytochrome P450 (CYP2C9) is the major metabolising enzyme for siponimod, accounting for 79.5% of metabolism in
Eintrag öffnenMayzent · 4.5 · During and for up to 4 weeks after treatment with siponimod vaccinations may be less effective. The efficacy o
Eintrag öffnenMayzent · 4.5 · During treatment initiation siponimod should not be concomitantly used in patients receiving class Ia (e.g. qu
Eintrag öffnenMayzent · 4.5 · Potential of other medicinal products to affect siponimod pharmacokinetics
Eintrag öffnenMayzent · 4.5 · Siponimod has not been studied in combination with antineoplastic, immune-modulating or immunosuppressive ther
Eintrag öffnenMayzent · 4.5 · The negative chronotropic effect of co-administration of siponimod and propranolol was evaluated in a dedicate
Eintrag öffnenMayzent · 4.8 · Blood pressure Hypertension was more frequently reported in patients on siponimod (12.6%) than in those given
Eintrag öffnenMayzent · 4.8 · Bradyarrhythmia Initiation of siponimod treatment results in a transient decrease in heart rate and may also b
Eintrag öffnenMayzent · 4.8 · Cases of meningitis or meningoencephalitis caused by varicella zoster viruses have occurred with siponimod at
Eintrag öffnenMayzent · 4.8 · Macular oedema Macular oedema was more frequently reported in patients receiving siponimod (1.8%) than in thos
Eintrag öffnenMayzent · 4.8 · Seizures Seizures were reported in 1.7% of patients treated with siponimod compared to 0.4% on placebo in the
Eintrag öffnenMayzent · 4.8 · The decrease in heart rate induced by siponimod can be reversed by atropine or isoprenaline.
Eintrag öffnenMayzent · 4.8 · The safety profile of siponimod was based on data from the core clinical study. The most common adverse reacti
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