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Begriffe zu „sotorasib“: Lumykras · 4.5 · 6 an acidic beverage (non-diet cola) decreased sotorasib Cmax by 32% and AUC by 23%. The clinical relevance ofLumykras · 4.5 · 7 Effect of sotorasib on P-gp substrates Co-administration of sotorasib with digoxin (a P-glycoprotein [P-gp] Lumykras · 4.5 · Acid-reducing agents Co-administration of sotorasib with a PPI (omeprazole) or an H2 receptor antagonist (famoLumykras · 4.5 · CYP2B6, CYP2C8, CYP2C9 and CYP2C19 substrates In vitro data indicated that sotorasib may have the potential toLumykras · 4.5 · CYP2D6 substrates In vitro data indicated that sotorasib may have the potential to inhibit CYP2D6, the clinica

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