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14 angezeigte Treffer · Seite 1, keine Gesamtzahl für „sotorasib“
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Lumykras · 4.5 · 6 an acidic beverage (non-diet cola) decreased sotorasib Cmax by 32% and AUC by 23%. The clinical relevance of
Eintrag öffnenLumykras · 4.5 · 7 Effect of sotorasib on P-gp substrates Co-administration of sotorasib with digoxin (a P-glycoprotein [P-gp]
Eintrag öffnenLumykras · 4.5 · Acid-reducing agents Co-administration of sotorasib with a PPI (omeprazole) or an H2 receptor antagonist (famo
Eintrag öffnenLumykras · 4.5 · CYP2B6, CYP2C8, CYP2C9 and CYP2C19 substrates In vitro data indicated that sotorasib may have the potential to
Eintrag öffnenLumykras · 4.5 · CYP2D6 substrates In vitro data indicated that sotorasib may have the potential to inhibit CYP2D6, the clinica
Eintrag öffnenLumykras · 4.5 · CYP3A4 substrates Sotorasib is a moderate CYP3A4 inducer. Co-administration of sotorasib with CYP3A4 substrate
Eintrag öffnenLumykras · 4.5 · Co-administration of sotorasib with midazolam (a sensitive CYP3A4 substrate) decreased midazolam Cmax by 48% a
Eintrag öffnenLumykras · 4.5 · Effect of sotorasib on other medicinal products
Eintrag öffnenLumykras · 4.5 · Effects of other medicinal products on sotorasib
Eintrag öffnenLumykras · 4.5 · In vitro studies indicate that sotorasib is metabolised by cytochrome P450 (CYP) 2C8, CYP3A4, and CYP3A5, and
Eintrag öffnenLumykras · 4.5 · Strong CYP3A4 inducers Co-administration of sotorasib with multiple doses of a strong CYP3A4 inducer (rifampic
Eintrag öffnenLumykras · 4.8 · Adverse drug reactions (ADRs) described in table 3 reflect exposure to sotorasib 960 mg once daily as monother
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