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Hycamtin · 4.5 · Cyclosporin A (an inhibitor of ABCB1, ABCC1 [MRP-1], and CYP3A4) administered with oral topotecan increased to
Eintrag öffnenHycamtin · 4.5 · Patients should be carefully monitored for adverse reactions when oral topotecan is administered with a substa
Eintrag öffnenHycamtin · 4.5 · The pharmacokinetics of topotecan were generally unchanged when co-administered with ranitidine.
Eintrag öffnenHycamtin · 4.5 · Topotecan does not inhibit human P450 enzymes (see section 5.2). In a population study using the intravenous r
Eintrag öffnenHycamtin · 4.5 · Topotecan does not inhibit human P450 enzymes (see section 5.2). In a population study using the intravenous r
Eintrag öffnenHycamtin · 4.5 · Topotecan is a substrate for both ABCB1 (P-glycoprotein) and ABCG2 (BCRP). Inhibitors of ABCB1 and ABCG2 admin
Eintrag öffnenHycamtin · 4.5 · When combining topotecan with other chemotherapy agents, reduction of the doses of each medicinal product may
Eintrag öffnenHycamtin · 4.5 · When combining topotecan with other chemotherapy agents, reduction of the doses of each medicinal product may
Eintrag öffnenHycamtin · 4.5 · When topotecan (0.75 mg/m2/day for 5 consecutive days) and cisplatin (60 mg/m2/day on day 1) were administered
Eintrag öffnenHycamtin · 4.8 · Additional adverse events were seen when topotecan was given in combination with cisplatin; however, these eve
Eintrag öffnenHycamtin · 4.8 · Complete alopecia related/possibly related to topotecan administration was observed in 9% of patients and part
Eintrag öffnenHycamtin · 4.8 · Fatigue was observed in approximately 25% and asthenia in 16% of patients receiving topotecan. Severe (Grade 3
Eintrag öffnenHycamtin · 4.8 · Other severe events that were recorded as related or possibly related to topotecan treatment were anorexia (12
Eintrag öffnenHycamtin · 4.8 · The integrated safety data for topotecan monotherapy are presented below.
Eintrag öffnenHycamtin · 4.8 · The safety profile of topotecan when given in combination with cisplatin in the cervical cancer clinical studi
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