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Trabectedin
Eintrag öffnenYondelis · 4.3 · - Hypersensitivity to trabectedin or to any of the excipients listed in section 6.1 - Concurrent serious or un
Eintrag öffnenYondelis · 4.5 · Alcohol consumption must be avoided during treatment with trabectedin due to the hepatotoxicity of the medicin
Eintrag öffnenYondelis · 4.5 · Effects of other substances on trabectedin
Eintrag öffnenYondelis · 4.5 · Preclinical data have demonstrated that trabectedin is a substrate to P-gp. Concomitant administration of inhi
Eintrag öffnenYondelis · 4.5 · Since trabectedin is metabolised mainly by CYP3A4, the concentrations of trabectedin in plasma are likely to b
Eintrag öffnenYondelis · 4.5 · When ketoconazole was co-administered with trabectedin, the plasma exposure of trabectedin was increased by ap
Eintrag öffnenYondelis · 4.5 · When rifampicin was co-administered with trabectedin, it resulted in reduced plasma exposure of trabectedin by
Eintrag öffnenYondelis · 4.8 · Capillary Leak Syndrome (CLS): Cases of Capillary Leak Syndrome (CLS) have been reported with trabectedin (inc
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