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20 angezeigte Treffer · Seite 1, keine Gesamtzahl für „trametinib“
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Mekinist · 4.5 · As trametinib is metabolised predominantly via deacetylation mediated by hydrolytic enzymes (e.g. carboxyl-est
Eintrag öffnenMekinist · 4.5 · Based on in vitro and in vivo data, trametinib is unlikely to significantly affect the pharmacokinetics of oth
Eintrag öffnenMekinist · 4.5 · Effect of food on trametinib
Eintrag öffnenMekinist · 4.5 · Effect of other medicinal products on trametinib
Eintrag öffnenMekinist · 4.5 · Effect of trametinib on other medicinal products
Eintrag öffnenMekinist · 4.5 · Patients should take trametinib as monotherapy or in combination with dabrafenib at least one hour prior to or
Eintrag öffnenMekinist · 4.5 · Potentiation of radiation treatment toxicity has been reported in patients receiving trametinib in combination
Eintrag öffnenMekinist · 4.5 · Trametinib is an in vitro substrate of the efflux transporter P-gp. As it cannot be excluded that strong inhib
Eintrag öffnenMekinist · 4.5 · When trametinib is used in combination with dabrafenib see sections 4.4 and 4.5 of the dabrafenib SmPC for int
Eintrag öffnenMekinist · 4.8 · 12 The safety of trametinib in combination with dabrafenib has been evaluated in the integrated safety populat
Eintrag öffnenMekinist · 4.8 · 14 Table 5 Adverse reactions with trametinib in combination with dabrafenib
Eintrag öffnenMekinist · 4.8 · 17 treatment with trametinib monotherapy or in combination with dabrafenib have liver function monitored every
Eintrag öffnenMekinist · 4.8 · Adverse reactions associated with trametinib obtained from clinical studies and post-marketing surveillance ar
Eintrag öffnenMekinist · 4.8 · Disorders associated with visual disturbances, including RPED and RVO, have been observed with trametinib. Sym
Eintrag öffnenMekinist · 4.8 · Elevations in blood pressure have been reported in association with trametinib as monotherapy and in combinati
Eintrag öffnenMekinist · 4.8 · Hepatic adverse reactions have been reported in clinical studies with trametinib as monotherapy and in combina
Eintrag öffnenMekinist · 4.8 · In clinical studies in other indications, the safety profile of trametinib in combination with dabrafenib in p
Eintrag öffnenMekinist · 4.8 · In the Phase III study with trametinib in patients with unresectable or metastatic melanoma (n=211), 49 patien
Eintrag öffnenMekinist · 4.8 · In the integrated safety population of trametinib in combination with dabrafenib (n=1 188) 27% of patients wer
Eintrag öffnenMekinist · 4.8 · New malignancies, cutaneous and non-cutaneous, can occur when trametinib is used in combination with dabrafeni
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