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18 angezeigte Treffer · Seite 1, keine Gesamtzahl für „vorasidenib“
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Voranigo · 4.5 · 6 In an in vivo drug-drug interaction study, co-administration of 20 mg vorasidenib with a strong CYP1A2 inhib
Eintrag öffnenVoranigo · 4.5 · Based on in vitro experiments vorasidenib is a strong inducer by means of pregnane X receptor (PXR) activation
Eintrag öffnenVoranigo · 4.5 · Co-administration of vorasidenib with CYP2B6, CYP2C8, CYP2C9, CYP2C19, or CYP3A4 substrates with narrow therap
Eintrag öffnenVoranigo · 4.5 · Co-administration of vorasidenib with moderate CYP1A2 inducers (phenytoin and rifampicin) may decrease vorasid
Eintrag öffnenVoranigo · 4.5 · Co-administration of vorasidenib with sensitive substrates of CYP2B6, CYP2C8, CYP2C9, CYP2C19, or CYP3A4 witho
Eintrag öffnenVoranigo · 4.5 · Co-administration of vorasidenib with strong CYP1A2 inhibitors (fluvoxamine and ciprofloxacin) may increase vo
Eintrag öffnenVoranigo · 4.5 · Effect of other medicinal products on vorasidenib
Eintrag öffnenVoranigo · 4.5 · Effect of vorasidenib on other medicinal products
Eintrag öffnenVoranigo · 4.5 · In vitro, vorasidenib is an inhibitor of breast cancer resistance protein (BCRP) (see section 5.2). Caution sh
Eintrag öffnenVoranigo · 4.5 · No clinically significant differences in vorasidenib pharmacokinetics were observed following co-administratio
Eintrag öffnenVoranigo · 4.5 · Vorasidenib may decrease concentrations of hormonal contraceptives and, therefore, concomitant use of a barrie
Eintrag öffnenVoranigo · 4.8 · Dose interruptions due to an adverse reaction occurred in 18.6% of patients treated with vorasidenib. The most
Eintrag öffnenVoranigo · 4.8 · Dose reductions of vorasidenib due to an adverse reaction occurred in 9.6% of patients. The most common advers
Eintrag öffnenVoranigo · 4.8 · In the INDIGO study, of the 167 patients treated with vorasidenib, 18.6% experienced elevations in ALT > 3 tim
Eintrag öffnenVoranigo · 4.8 · Permanent discontinuation of vorasidenib due to grade ≥ 3 ALT increased or autoimmune hepatitis was reported i
Eintrag öffnenVoranigo · 4.8 · Table 3: Adverse drug reactions reported in patients treated with vorasidenib
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