Salvia miltiorrhiza Bunge (Danshen) · interaction review discussion

Reduce Platelet Aggregation

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Salvia miltiorrhiza Bunge (Danshen): The dried radix et rhizome of Salvia miltiorrhiza Bunge has the functions of promoting blood circulation and removing blood stasis, relieving pain by dredging meridians, clearing heart fire, relieving restlessness, and cooling blood to diminish carbuncle. Modern pharmacological effects are anti-coagulation, anti-thrombosis, improvement of microcirculation, improvement of blood rheology, anti-myocardial ischemia, anti-cerebral ischemia, anti-oxidation, etc. In vivo (Fan et al., 2010), salvianolic acid A (SAA) did not affect coagulation parameters in rats after intravenous administration for five successive days. In vitro, pretreatment with SAA on washed rat and human platelets significantly inhibited various agonists, stimulated platelet aggregation and caused an increase in cyclic adenosine monophosphate (cAMP) level in platelets activated by adenosine diphosphate (ADP). SAA possesses antithrombotic activities. The antithrombotic effect might be related to its antiplatelet action and ability to modulate hemorheology without affecting the coagulation system. The mechanisms underlying such activities may involve the induction of cAMP. Li Le reported that Salvia miltiorrhiza can increase the activity of coagulation factor Ⅲ and fibrinolysis by inhibiting platelet aggregation, and can reduce the clearance rate of warfarin to enhance its anticoagulant effect (Li L. et al., 2016). A pharmacological study by Xie H.J. et al. showed that Salvia miltiorrhiza has the effect of anti-platelet aggregation, but does not affect blood coagulation function in rats (Xie et al., 2009). When combined with warfarin, it can increase the steady-state blood concentration and INR of warfarin in rats, and enhance the anticoagulation of warfarin.

Befund HOS-368740 · warfarin · HOS-085950 · Originalquelle ↗

Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update ↗

Copyright © 2021 Zhuang, Liu, Zhao, Sun, He, Wang, Jia, Lin, Chu and Xi. Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update. DOI: 10.3389/fphar.2021.751107 · CC BY 4.0

Quellen-Hash: b46c221ac01dd09600094fcfc243f39e7e1846720f413ea49157075cd642ed78

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