Salvia miltiorrhiza Bunge (Danshen) · interaction review discussion

Reduction of Warfarin Metabolism

Quellenbefund mit unverändertem Untersuchungskontext. Klinischer Schweregrad: nicht bewertet.

Salvia miltiorrhiza Bunge (Danshen): Wang et al. (2010a) studied human cells and showed that tanshinone I, tanshinone IIA and cryptotanshinone strongly inhibited CYP1A2, moderately inhibited CYP2C9, tanshinone I and cryptotanshinone, weakly inhibited CYP3A4, dihydrotanshinone and competitively inhibited CYP1A2 and CYP2C9, but had no effect on CYP3A4. Qiu et al. (2008), Wang (2015) investigated the effects of various components of Salvia miltiorrhiza Bunge on the activity of cytochrome P450s (CYPs) in humans and found that cryptotanshinone, tanshinone I and tanshinone IIA competitively inhibited CYP1A2, cryptotanshinone and tanshinin moderately inhibited CYP2C9, protocatechualdehyde slightly inhibited CYP3A4, while the lipid soluble components of Salvia miltiorrhiza Bunge could induce CYP3A4. Wang et al. (2009), Wang et al. (2010b) showed in both in vivo and ex vivo experiments in rats that tanshinones inhibited the activity of CYP2C11, but had fewer pharmacodynamic effects on the CYP2C11-specific substrate toluene sulfonylurea, which had the same specific metabolic substrate as human CYP2C9, therefore it can be concluded that various components of Salvia miltiorrhiza Bunge may affect the anticoagulant effect of warfarin by inhibiting CYP2C9 and CYP1A2, inhibiting or inducing CYP3A4, and competitively binding to human albumin and other ways. Wu and Yeung (2010) also found that tanshinone reduced CYP1A1, CYP2C6 and CYP2C11 mediated 4-, 6- and 7-hydroxywarfarin hydroxylation reactions in rats, thereby inhibiting warfarin metabolism. Zhou et al. (2012) also concluded that Salvia miltiorrhiza Bunge affected the anticoagulant effect of warfarin in relation to CYP450 enzyme metabolism.

Befund HOS-368741 · warfarin · HOS-085950 · Originalquelle ↗

Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update ↗

Copyright © 2021 Zhuang, Liu, Zhao, Sun, He, Wang, Jia, Lin, Chu and Xi. Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update. DOI: 10.3389/fphar.2021.751107 · CC BY 4.0

Quellen-Hash: b46c221ac01dd09600094fcfc243f39e7e1846720f413ea49157075cd642ed78

• Fan H. Y. Fu F. H. Yang M. Y. Xu H. Zhang A. H. Liu K. (2010). Antiplatelet and Antithrombotic Activities of Salvianolic Acid. A. Thromb. Res. 126, e17–e22. 10.1016/j.thromres.2010.04.006
• Li L. Cheng X. Wang J. J. (2016a). The Research Progress of TCM Injections with Warfarin Drug Interactions. Chin. J. Geriatr. Care 14, 59–61. 10.3969/j.issn.1672-4860.2016.03.029
• Xie H. J. Fu H. Y. Zhu C. F. Huang Z. Charles D. S. (2009). Effects of Danshen Injection (Salvia Miltiorrhiza) on Pharmacodynamics and Pharmacokinetics of Warfarin in Rats. Herald Med. 28, 36–39. 10.3870/yydb.2009.01.011
• Wang X. Cheung C. M. Lee W. Y. Or P. M. Yeung J. H. (2010a). Major Tanshinones of Danshen (Salvia Miltiorrhiza) Exhibit Different Modes of Inhibition on Human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 Activities In Vitro . Phytomedicine 17, 868–875. 10.1016/j.phymed.2010.05.003
• Qiu F. Zhang R. Sun J. Jiye A. Hao H. Peng Y. (2008). Inhibitory Effects of Seven Components of Danshen Extract on Catalytic Activity of Cytochrome P450enzyme in Human Liver Microsomes. Drug Metab. Dispos. 36, 1308–1314. 10.1124/dmd.108.021030
• Wang Y. J. (2015). Different Effects of Four Ingredients of Danshen on the CYP3A4 and CYP2C9 Expressions. Shanghai: Shanghai Jiaotong University.
• Wang X. D. Li J. L. Su Q. B. Guan S. Chen J. Du J. (2009). Impact of the Haplotypes of the Human Pregnane X Receptor Gene on the Basal and St John’s Wort-Induced Activity of Cytochrome P450 3A4 Enzyme. Br. J. Clin. Pharmacol. 67, 255–261. 10.1111/j.1365-2125.2008.03344.x
• Wang X. Lee W. Y. Or P. M. Yeung J. H. (2010b). Pharmacokinetic Interaction Studies of Tanshinones with Tolbutamide, a Model CYP2C11 Probe Substrate, Using Liver Microsomes, Primary Hepatocytes and In Vivo in the Rat. Phytomedicine 17, 203–211. 10.1016/j.phymed.2009.07.013
• Wu W. W. Yeung J. H. (2010). Inhibition of Warfarin Hydroxylation by Major Tanshinones of Danshen in the Rat In Vitro and In Vivo . Phytomedicine 17, 219–226. 10.1016/j.phymed.2009.05.005
• Zhou X. Chan K. Yeung J. H. (2012). Herb-drug Interactions with Danshen (Salvia Miltiorrhiza): a Review on the Role of Cytochrome P450 Enzymes. Drug Metabol. Drug Interact. 27, 9–18. 10.1515/dmdi-2011-0038
• Lo A. C. Chan K. Yeung J. H. K. Woo K. S. (1992). The Effects of Danshen (Salvia Miltiorrhiza) on Pharmacokinetics and Pharmacodynamics of Warfarin in Rats. Eur. J. Drug Metab. Pharmacokinet. 17, 257–262. 10.1007/BF03190157
• Tan Y. Z. Wu A. C. Tan B. Y. Wu Y. H. Tang L. F. Li J. H. (2002). Study on the Interactions of Berberine Displace Other Drug from Their Plasma Proteins Binding Sites. Chin. Pharmacol. Bull. 18, 576–578.
• Liu J. Wang X. Cai Z. Lee F. S. (2008). Effect of Tanshinone IIA on the Noncovalent Interaction between Warfarin and Human Serum Albumin Studied by Electrospray Ionization Mass Spectrometry. J. Am. Soc. Mass. Spectrom. 19, 1568–1575. 10.1016/j.jasms.2008.06.005
• Guo L. Zheng D. R. (2009). The Influence of Compound Danshen Dropping Pill in Coronary Heart Disease on PT, APTT and FIB. Chin. Med. Herald 6, 87–88. 10.3969/j.issn.1673-7210.2009.18.050
• Wang Q. (2013). Studies on FXa Inhibitors of Herba Lycopi and Salvia Mitiorrhizae. Nanjing: Nanjing University of Chinese Medicine.